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June 06-07, 2019 | London, UK
2
nd
International Conference on
Tissue Science and Molecular Biology,
Stem Cells & Separation Techniques
Joint Event
Biomedical Research (An International Journal of Medical Sciences) | ISSN: 0976-1683 Volume 30
The combination of photodynamic therapy with anti-angiogenic therapy for the
effective control of local prostatic tumor and distant metastasis
Mohamed Abd Ellatif
King Khalid University, Saudi Arabia
T
he Combination of anti-angiogenic therapy with cytotoxic
therapy has shown positive outcome in various preclinical
studies. However, these promising results did not always
translate to clinical efficacy, demonstrating the complexity of
combination strategies. As a result, there are ongoing efforts
to combine existing cytotoxic therapy with anti-angiogenic
therapytoenhancetheefficacyofcancertreatment.However,
the optimal scheduling of anti-angiogenic therapy with
cytotoxic therapy, although crucial for maximizing treatment
efficacy remains unclear. The aimof this study is to investigate
VEGF regulation following cytotoxic therapy as a basis for the
efficacy of combination anti-angiogenic therapy. Materials
and methods: Orthotopic prostate tumors were implanted
in the prostate of 6-week-old male severe combined
immunodeficient mice. In particular, we investigated the
effect of the combination treatment strategy on the two
major patterns of metastasis: hematogenous as well as
lymphatic metastasis. Here, we investigated an optimal
protocol for combining Avastin anti-angiongenic therapy
with photodynamic therapy (PDT), a cytotoxic therapy for
various diseases including cancer. We demonstrate that
PDT leads to a temporally transient regulation of vascular
endothelial growth factor (VEGF) following treatment. More
importantly, combination Avastin therapy was most effective
in inhibiting lung metastasis when delivered around the peak
of VEGF response following PDT. Considering that temporally
transient VEGF regulation was observed following PDT,
radiotherapy and chemotherapy. In conclusion, PDT lead
to a temporally transient regulation of vascular endothelial
growth factor (VEGF) following treatment. Considering that
temporally transient VEGF regulation was observed following
PDT, radiotherapy and chemotherapy, optimal scheduling
of combination anti-angiogenic therapy based on temporal
dynamics of the VEGF response has implications in a wide
range of cancer treatments.
e
:
mabdellatif2000@yahoo.comBiomed Res, Volume 30
ISSN: 0976-1683