13 / 27
allied
academies
Page 50
June 06-07, 2019 | London, UK
2
nd
International Conference on
Tissue Science and Molecular Biology,
Stem Cells & Separation Techniques
Joint Event
Biomedical Research (An International Journal of Medical Sciences) | ISSN: 0976-1683 Volume 30
Translation of basic research into cell-based therapies in tissue regeneration
Madhu Dhar, David E Anderson, Henry S Adair, James Schumacher
and
Dennis Geiser
University of Tennessee, USA
T
he large animal regenerative medicine program, started
in 2010 conducts research in the use of mesenchymal
stem cells, biomaterials and other forms of cell-based
therapies that will translate to both veterinary and human
medicine. Our ultimate goal is to make basic discoveries
and to expand these discoveries into the development of
diagnostic modalities and treatment protocols to solve
complex medical problems related to musculoskeletal, and
nerve injuries. We carry out specific
in vitro
assays to evaluate
cell adherence, proliferation and potential for differentiation
into osteocytes, chondrocytes or neural-like progenitors. We
then conduct controlled studies, using rodents, to confirm
the biocompatibility and efficacy of mesenchymal cells
used alone or in combination with biomaterials. Finally, we
translate these findings into controlled, preclinical studies
using large animals, including goats, sheep, pigs and horses.
We perform the
in vitro
and rodent studies to improve clinical
outcomes for large animal and human patients.
e
:
mdhar@utk.eduBiomed Res, Volume 30
ISSN: 0976-1683