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Biomedical Research
|
Volume 29
Page 61
allied
academies
CARDIOLOGY AND CARDIOVASCULAR MEDICINE
STEM CELLS AND REGENERATIVE MEDICINE
&
International Conference on
International Conference on
J u n e 1 8 - 1 9 , 2 0 1 8 | O s a k a , J a p a n
Joint Event on
A NOVEL S100A8/A9 INDUCED FINGERPRINT OF MESENCHYMAL
STEM CELLS IS ASSOCIATED WITH ENHANCED WOUND HEALING
Abjihit Basu
Ulm University, Germany
W
e here investigated a unique capacity of mesenchymal stem cells (MSCs) to re-establish tissue homeostasis using
their premonitory potential to sense danger associated molecular pattern (DAMP) and to mount an adaptive response
in the interest of tissue repair. Injection of MSCs pretreated with heterodimeric DAMP protein S100A8/A9 into murine
full-thickness wounds, led to a significant acceleration of healing even exceeding that of wounds with non-treated MSCs.
This correlates with a fundamental reprogramming of the transcriptome in S100A8/A9 treated MSCs as deduced from in-
depth validation via global RNAseq, RT-PCR, and immunostaining. We uncovered a network of genes/proteins involved in
proteolysis, enhancing macrophage phagocytosis and controlling inflammation, all contributing to profound clean-up of the
wound site as well as genes encoding specific extracellular matrix proteins of scar-reduced embryonic tissue repair. This
novel MSC transcriptome not only underscores the concept that MSCs are endowed with the unique property of perfectly
controlling multiple cells but also holds substantial promise that MSC-based therapies could be extrapolated using refine
inductors for fast wound closure.
Dr.Abhijitbasu@gmail.comBiomed Res 2018, Volume 29 | DOI: 10.4066/biomedicalresearch-C2-006