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Biomedical Research

Volume 29

Page 56

allied

academies

CARDIOLOGY AND CARDIOVASCULAR MEDICINE

STEM CELLS AND REGENERATIVE MEDICINE

International Conference on

J u n e 1 8 - 1 9 , 2 0 1 8 | O s a k a , J a p a n

Joint Event on

EVALUATION OF HEMATOPOIETIC PROGENITOR CELLS IN

PATIENTS WITH TRAUMA HEMORRHAGIC SHOCK AND ITS

CORRELATION WITH OUTCOMES

A Manoj Kumar

NIMS University, India

Background:

Hemorrhagic shock accounts up to 50% of early trauma deaths. Hematopoietic failure has been observed in

experimental animals and human following shock and injury. One of the facets of bone marrow failure is multiple organ

dysfunction syndrome and is commonly seen in patients recovering from severe trauma and hemorrhagic shock. Bone

Marrow (BM) dysfunction is associated with mobilization of hematopoietic progenitor cells (HPCs) into peripheral blood.

Present study explored the association of peripheral blood HPCs with mortality in trauma hemorrhagic shock patients (T/

HS).

Material and Methods:

Prospective cohort studies of patients presenting within 8 hrs of injury with T/HS to the Department

of Emergency Medicine, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences were recruited.

Peripheral blood samples were collected in each patient for measurement of peripheral blood HPCs. Peripheral blood

progenitor cell (PBPC) quantification was performed by measuring HPCs counts using the hematology analyzer (Sysmex

XE-2100). Clinical and laboratory data were prospectively collected after consent. Ethical approval was taken and data was

analysed by Stata 11.2.

Results:

39 patients with trauma hemorrhagic shock and 30 normal healthy controls were recruited. HPCs were significantly

higher (P < 0.001) in the T/HS as compared to control. Among study group, 14 patients died within 24 h. at the hospital

admission, and found HPCs concentrations were highly significant (<0.001) in non-survivors (n = 14) when compared with

survivors (n = 25) among T/HS patients.

Conclusions:

Our studies suggest the peripheral blood HPCs may be early prognostic marker for mortality among patients who

presented with trauma hemorrhagic shock on admission.

Biomed Res 2018, Volume 29 | DOI: 10.4066/biomedicalresearch-C2-006