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Biomedical Research
|
Volume 29
Page 60
allied
academies
CARDIOLOGY AND CARDIOVASCULAR MEDICINE
STEM CELLS AND REGENERATIVE MEDICINE
&
International Conference on
International Conference on
J u n e 1 8 - 1 9 , 2 0 1 8 | O s a k a , J a p a n
Joint Event on
IMPLANT OF AUTOLOGOUS ADULTS BONE MARROW STEM
CELLS IN HEART FAILURE, FUNCTIONAL CLASS IV
Matias Fernandez Vina
Clinica San Nicolas, Argentina
Objetives:
(1) Demonstrate that CD34 + / CD38 (-) Adult Stem Cells in myocardial tissue generate a significant increase
in the ejection fraction after implantation. (2) To observe the improvement in the quality of life of the implanted patients,
evaluating the reduction of dyspnea and the number of hospitalizations.
Material and methods:
A descriptive, observational study of 71 and 88 -year-old patients with a history of CF IV heart
failure with severe deteriorated FEY (<30%) who suffered hospitalizations every 15 days, due to biventricular dysfunction.
They were submitted to implantation of bone marrow Stem Cells through retrograde venous technique in coronary sinus
with balloon occlusion by femoral catheterization. A pre / post implant echocardiogram was indicated for comparisons (7
months) and a post-implant effort ergometry test was performed.
Results:
After a period of 210 days, a significant improvement in the ejection fraction of approximately 8% and 14% was
observed with respect to the baseline (P:0.05), and a decrease in both hearts mass of 20% (grams). In addition, it was
observed that the patients did not have recurrence in hospital admissions successively every 15-20 days, cause congestive
heart failure and that there is a remarkable improvement in the quality of life rapidly after the implantation of Stem Cells.
The post-implant ergometry test, at 210 days, turned out to be encouraging, since the patient tolerated the stress test
greater than 6 minutes.
Conclusion:
The implantation of Stem Cells generated a favorable decrease in the number of hospital readmissions of the
evaluated patients and showed improvement of their quality of life after no dyspnea CF IV. It was corroborated that there is
a significant improvement of the ejection fraction, with decrease of the mass of the implanted organ.
matiasfernandezvina@hotmail.comBiomed Res 2018, Volume 29 | DOI: 10.4066/biomedicalresearch-C2-006