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Biomedical Research
|
Volume 29
Page 53
Note:
allied
academies
CARDIOLOGY AND CARDIOVASCULAR MEDICINE
STEM CELLS AND REGENERATIVE MEDICINE
&
International Conference on
International Conference on
J u n e 1 8 - 1 9 , 2 0 1 8 | O s a k a , J a p a n
Joint Event on
STENTS WITH GROWTH FACTOR SECRETING MSCS ENHANCED
RE-ENDOTHELIALIZATION AND DECREASED RESTENOSIS IN
SWINE MODEL
Hyun-Kyung
Seoul National University, South Korea
C
urrently, cardiac stenting is the most effective and least invasive approach to treating the disease. However, in-stent
restenosis is a complex chronic side-effect of the stenting treatment. In this study, to reduce stent restenosis and induce re-
endothelialization within the artery, we applied coronary stents coated with stem cells secreting angiogenic growth factors via an
inducible genome-editing system. After confirming the characteristics of the cells and their adhesion properties on the stents, we
transplanted the stents into a swine model to evaluate the restenosis and potential therapeutic use of the stents with stem cells.
Restenosis was evaluated via optical coherence tomography (OCT), micro-computed tomography (mCT) and angiography, and re-
endothelialization by immunostaining after cardiac stent treatment. Compared to a bare metal stent (BMS) or a parental umbilical
cord blood-derived mesenchymal stem cells (UCB-MSC)-coated stent, the stents that had stem cells capable of the controlled
release of hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF) successfully reduced re-stenosis within
the stent and induced natural re-endothelialization. Furthermore, UCB-MSCs exhibited the ability to differentiate into endothelial
cells in Matrigel, and HGF and VEGF improved the differentiation. Our study indicates that the stents coated with UCB-MSCs
secreting VEGF/HGF reduced the restenosis side effects of cardiac stenting with improved re-endothelialization.
icandoithk@snu.ac.krBiomed Res 2018, Volume 29 | DOI: 10.4066/biomedicalresearch-C2-006