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Biomedical Research
|
Volume 29
Page 51
allied
academies
CARDIOLOGY AND CARDIOVASCULAR MEDICINE
STEM CELLS AND REGENERATIVE MEDICINE
&
International Conference on
International Conference on
J u n e 1 8 - 1 9 , 2 0 1 8 | O s a k a , J a p a n
Joint Event on
PREVALENCE OF CORONARY ARTERY DISEASE DETECTED
BY MYOCARDIAL PERFUSION SCINTIGRAPHY IN PATIENTS
OF ESSENTIAL HYPERTENSION WITH OR WITHOUT
DIABETES MELLITUS
Owais Qadeer Gill
PINUM Hospital, Pakistan
Purpose:
Aim of this retrospective study was to find prevalence of coronary artery disease (CAD) in hypertensive patients with or
without diabetes mellitus.
Materials and methods:
Data of patients having essential hypertension (n=931) referred to PINUM for myocardial perfusion
scintigraphy (MPS) was analyzed. This datawas divided into two groups: HDMgroup contains data of patients having hypertension
with diabetes mellitus (n=456, 48.9% of total, M: F=245:211). While data of patients having hypertension without diabetes mellitus
was placed in H group (n=475, 51.0% of total, M: F=254:221). Mean age was 52.4 + 10.2years in HDM group and 48.7 + 10.9years
in H group. Duration of hypertension was 5.2 + 5.0years in HDM group and 5.6 + 5.5years in H group. Duration of diabetes mellitus
was 7.0 + 5.8years in HDM group. Each group was divided into subgroups based on gender, clinical presentation and age. Patients
with perfusion defects on MPS were considered to have CAD.
Results:
Prevalence of CAD is higher in HDM group than H group subjects (47.8% vs. 30.1%; p<0.001). Prevalence of CAD is higher
inmales than females in HDM (53.9 % vs. 40.8%) and H groups (39.4% vs. 19.5%) respectively. The difference of prevalence of CAD
in HDM and H groups is more marked in females (40.8% vs. 19.5%; p<0.001) than males (53.9 % vs. 39.4%; p=0.001). Prevalence
of CAD in patients with typical presentation is not statistically significant in HDM and H groups (72.3% vs. 68.4%; p=0.645), while
in subjects with atypical presentation, prevalence is significantly higher in HDM than H group (40.8% vs. 26.8%; p<0.001).
Conclusion:
Prevalence of CAD is higher in the HDM group than the H group. Prevalence of CAD is higher in males than females
in both groups. Prevalence is almost similar in patients with typical presentation in both groups. While with atypical presentation,
prevalence of CAD is significantly higher in HDMgroup. Prevalence of CAD increases with age in both groups. However in females,
this increase in prevalence with age is markedly slower till the age of 65years. After 65, prevalence of CAD in females approaches
to that in males.
Biomed Res 2018, Volume 29 | DOI: 10.4066/biomedicalresearch-C2-006