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Biomedical Research
|
Volume 29
Page 46
allied
academies
CARDIOLOGY AND CARDIOVASCULAR MEDICINE
STEM CELLS AND REGENERATIVE MEDICINE
&
International Conference on
International Conference on
J u n e 1 8 - 1 9 , 2 0 1 8 | O s a k a , J a p a n
Joint Event on
EVALUATION OF [
64
Cu] PYRUVALDEHYDE-BIS (N4-
METHYLTHIOSEMICARBAZONE) AN ATTRACTIVE
RADIOPHARMACEUTICAL FOR MYOCARDIAL PERFUSION FOR PET
Juan C Manrique Arias
Instituto Nacional de Cancerología & Universidad Nacional Autónoma de México, Mexico
C
opper (Cu) is an important trace element in humans; Due to its decay characteristics, Cu-64 (T
1/2
=12.7h, β
+
[17.4%], β
-
[39%], E.C. [43.6%]) is an attractive radionuclide with applications in both, PET Copper molecular imaging and targeted
therapy. This radionuclide has been widely used in the labelling of macromolecules such as peptides, proteins, monoclonal
antibodies, and thiosemicarbazone complexes, [
64
Cu]Cu(II)-pyruvaldehyde-bis(N
4
-methyl-thiosemicarbazone) ([
64
Cu]Cu(II)-
PTSM), a tracer for myocardial perfusion, Cu-64 is produced via the
64
Ni(p,n)
64
Cu, nuclear reaction. [
64
Cu]-PTSM is prepared
using in-house made PTSM ligand and [
64
Cu] chloride. Radiochemical purity of [
64
Cu]-Cu(II)-PTSM is higher than 98%. Cu(II)
bis(thiosemicarbazone) complex as myocardial perfusion agents, labelled with positron emitters of Cu with half-lives
suitable for its regional distribution from a satellite Centre.
juancmanriquea@unam.mxBiomed Res 2018, Volume 29 | DOI: 10.4066/biomedicalresearch-C2-006