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Journal of Dermatology Research and Skin Care | Volume 2
May 14-15, 2018 | Montreal, Canada
Spring Dermatology &
Skin Care Expo Conference
The Tissue Biology Research Unit (TBRU) in Zurich has
bio-engineered innovative autologous skin grafts for the
treatment of skin defects and abnormalities such as burns,
chronic wounds, wounds caused by tumor resection and
infections. Our skin grafts can reach up to 70 times the size of
the original biopsy in a relatively short time (min 12 days for
a dermal graft, 20 days for a dermo-epidermal graft). After
transplantation, the bio-engineered autologous skin grafts
permanently remain on the patient and replace skin in its
full thickness. Phase I clinical studies for one of our products
(denovoSkin) are now completed. Results in terms of safety
(and already efficacy) are very promising. Multicentric Phase
II studies have started in late 2017 in six different clinical
centers in Switzerland, the Netherlands and Great Britain.
Orphan Drug Designation (ODD) for the treatment of burn
injuries has been reached for denovoSkin in Europe (EMA),
Switzerland (Swissmedic) and the USA (FDA). Our present
research focuses on the development of even more complex
skin grafts which will comprise pigmentation (to match the
skin color of the patient), and the establishment of a dermal
network of blood capillaries (to fasten take and regeneration
after transplantation). A corresponding product is close to
being used at the bed-side. Pre-clinical studies (including
proof of concept and toxicological studies) have already
been conducted. Establishment of the GMP production of
this product is ongoing and within reach. First-in-man trials,
on both adults and children, are foreseen for late 2018.
Speaker Biography
Ernst Reichmann is currently in Tissue Biology Research Unit as a Group Head and
Professor in Switzerland. He is the author of over 60 publications, in peer-reviewed
journals. He is a reviewer for multiple journals with positions in others. His expertize
includes an interest in the Tissue Biology of skin grafts including dermatological
diseases.
e:
Novel bio-engineered dermo-epidermal skin grafts: A report on phase I clinical data and new
experimental findings
Ernst Reichmann
Tissue Biology Research Unit, Switzerland