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Journal of Dermatology Research and Skin Care | Volume 2
May 14-15, 2018 | Montreal, Canada
Spring Dermatology &
Skin Care Expo Conference
In recent years, the role of cellular receptors that lead to the
production of nuclear factor kappa B in the etiopathogenesis
of acne vulgaris (AV) has been studied, with a growing
number of new therapies clinical trials. Therefore, it is
important to contribute with immunohistochemical analysis
description in AV to best compare this treatments result.
Methods: 19 male patients with papulopustular acne
without any treatment for at least 30 days were included
in this study and back inflammatory lesions biopsis were
made for immunohistochemical analysis in all of them. The
cells stained with antibodies to receptor-activated receiver
proliferator gamma (PPAR-γ) and nucleotide-binding
oligomerization domain-like receptors (NOD) 1 e 2 were
analyzed by optical microscopic reading of light held by two
experienced observers, subjectively, and the results grouped
into non-existent expression (0), low (1), medium (2) and
high (3) immunological cells in the epidermis (EP), sebaceous
glands (SG) and hair follicles (HF). The data were assessed by
median (M), with minimum (mn) and maximum (max) values
[M (mn, max)].
Results: To PPAR-y there were found values EP 2 (0,3), SG 2
(1,3) and HF 1(0,3); to NOD1, EP 3 (1,3), SG 2 (1,3) and HF
2(0,3) and to NOD2, EP 2 (1,3), SG 2 (0,3) and HF 1(0,2).
Conclusions: It seems that these receptors are well
distributed em key structures in papulopustular acne and
therapeutic opportunities for pharmacological modulation
must be explored
Speaker Biography
Clarissa Prati is an Italian-Brazilian Dermatologist with an MSc in Clinical Medicine.
Currently, she is a PhD student in Health Sciences, São Paulo, SP, Brazil, and Mentor
in Pediatric Dermatology at Pontificia Universidade Católica RS/São Lucas Hospital,
Porto Alegre, RS, and Brazil. She also has a private office in Porto Alegre, RS, and Brazil,
wherein she explores her expertise in clinical and cosmetic dermatology, aside of
being the President of State of Rio Grande do Sul’s section of the Brazilian Society of
Dermatology.
e:
Assessment of immunohistochemical aspects in papulopustular
Clarissa Prati
Brazilian Society of Dermatology, Brazil