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Journal of Dermatology Research and Skin Care | Volume 2
May 14-15, 2018 | Montreal, Canada
Spring Dermatology &
Skin Care Expo Conference
Introduction:
The sebaceous glands secretion in acne vulgaris
(AV)iscomposedoflipidswithadecreaseoffreefattyacids(FFA),
especially linoleic acid (AL). It unprotects the glandular epithelial
wall, which is assaulted by FFA hydrolyzed of triglycerides by the
P. acnes lipase. The role of cellular receptors that lead to the
production of nuclear factor kappa B in the etiopathogenesis of
AV has been studied in new therapies clinical trials.
Hypothesis:
Oral supplementation of AL in patients with AV
interferes with the expression of the receptor-activated receiver
proliferator gamma (PPAR-γ).
Methods:
Nineteen patients with papulopustular acne received
for90days:GroupA,300mg/dayoflymecycline;GroupB,540mg
gamalinoleico acids, 510mg linoleic and oleic 1200mg/day;
Group C: groups A+B. In the initial and final visits, inflammatory
lesions biopsies were made for immunohistochemical analysis.
The cells stained with antibody PPAR-γ were analyzed by two
experienced observers and the results grouped into non-
existent expression (0), low (1), medium (2) and high (3) in
the epidermis, sebaceous glands and hair follicles. The results
obtained before and after the treatments were compared,
as well as the groups with each other, with data assessed by
median.
Results:
There was a reduction tendency in the PPARG marking
of the interanexial epithelium in the Group C (median values:
2,5 before and 1,5 after treatment).
Conclusion:
Even though this study has limits inherent to the
restricted sample, it´s seems like lymecyclineworks better when
associated with AL supplementation in the papulopostular acne
treatment.
Speaker Biography
Clarissa Prati is an Italian-Brazilian Dermatologist. She has completed her MSc in
Clinical Medicine. Currently, she is a PhD student in Health Sciences, São Paulo, SP,
Brazil, mentor in Pediatric Dermatology at Pontific Universidade Católica RS/São Lucas
Hospital, Porto Alegre, RS, Brazil. She has also a private office in Porto Alegre, RS,
Brazil, wherein she explores her expertise in clinical and cosmetic dermatology, aside
of being the President of State of Rio Grande do Sul’s Section of the Brazilian Society
of Dermatology.
e:
prati@terra.com.brClarissa Prati
Brazilian Society of Dermatology, Brazil
Assessment of cutaneous effects secondary to oral supplementation with omega-3,
-6 and -9 exclusive or associated with tetracycline, in the skin of patients with
papulopustular acne - Preliminary results