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Journal of Nutrition and Human Health | Volume 3
May 23-24, 2019 | Vienna, Austria
Joint Event
2
nd
International Conference on
Gastroenterology and Digestive Disor
ders
17
th
International Conference on
Nutrition and Fitness
&
Gastric fermentation in functional dyspepsia
Barrios Adriana, Barrios Antonio, Dunsford Matthew, Alvarez Angela, Tzorin Dominga
and
Paz Jose Miguel
Las Torres Clinic Quetzaltenango, Guatemala
Background/Aims:
The role of the gastric fermentation in
functional dyspepsia has been investigated.
Methods:
Lactulose Hydrogen Breath test,
H. pylori
13C Urea
Breath Test. 47 patients with functional dyspepsia (FD) has
been investigated.
Results:
Positives for lactulose hydrogen breath test (SIBO)
23, negatives (SIBO) 24.
H. pylori
and hydrogen breath test (SIBO) positives 12.
Introduction:
At least 20% of the population has
chronic symptoms that can be attributed to disorders of
gastroduodenal function, and the majority of these people
have no evidence of organic causes. Diagnostic criteria:
One or more of the following bothersome: postprandial
fullness, early satiation, epigastric pain, epigastric burning
and no evidence of structural disease, (including a upper
endoscopy) that is likely to explain the symptom onset at
least 3 months with symptom onset at least 6 months
before diagnosis. (1) The bacterium
Helicobacter pylori
is
found in 40% of the population and is responsible for the
development of the duodenal ulcer disease. The infection
also is a cause of gastric ulcer diseases, and of some cases
of non-ulcer dyspepsia and gastric adenocarcinoma (2). In
an analogous way, the post-infectious in the IBS (Irritable
Bowel Syndrome), several studies have identified the
novo
development of FD following an enteric infection.
Giardia
lamblia
infection has been shown to provoke visceral
hypersensitivity and delay gastric emptying. Besides the
bacteria
E.coli
in gastric infection can produce dismotility
(3).The latest iteration of the Rome IV, published in 2016,
represents a significant departure from prior version with
a much broader approach to the definition and potential
pathophysiology of functional gastrointestinal disorders
and now recognizes the possible contribution of such
phenomena as low-grade inflammation, changes in the gut
microbiota, and altered brain processing to the pathogenesis
of the symptoms (3). Finally, the growth of bacteria was
demonstrated with culture of gastric biopsy (4).
Hydrogen breath test using various substrates like glucose,
lactulose, lactose and fructose are being used more and
more to diagnose small intestinal bacterial overgrowth (SIBO)
and lactose or fructose malabsorption. Though quantitative
culture of jejunal aspirate is considered as gold standard for
the diagnosis of SIBO, hydrogen breath test, in spite of their
low sensitivity, are popular for their non-invasiveness. (5).
e
:
adrianabarriosmd@gmail.com