16 / 25
allied
academies
Page 49
Notes:
Journal of Nutrition and Human Health | Volume 3
May 23-24, 2019 | Vienna, Austria
Joint Event
2
nd
International Conference on
Gastroenterology and Digestive Disor
ders
17
th
International Conference on
Nutrition and Fitness
&
Towards a personalized approach to promote Musculoskeletal and Cardiovascular
Fitness
Flück Martin
University of Zurich, Switzerland
H
uman Health and performance depends on
constitutional factors and is conditioned by nutritional
cues. Specifically metabolic fitness and strength are
key variables to protect against morbidity by enhancing
mobility and quality of life that are potently conditioned
by the nutritional stimulus of regular intense exercise. In
recent decades is has become increasingly evident that
a considerable inter-individual capacity resides in the
human population regarding the outcome of exercise
training interventions on performance. This allows some
individuals to improve maximal oxygen uptake efficiently
while others nearly fail to respond to the stimulus.
Through the study of the cellular pathways underlying
skeletal muscle’s malleability to exercise training in
untrained andmoderately subjects, and high-level athletes,
we have identified that the capacity to improve muscle
metabolism is reflected in a specific molecular signature
that is graded to the volume and intensity of the impacting
mechanical and metabolic stimuli during exercise. We
have identified natural variants (i.e. polymorphisms) in
the genes of the angiotensin-tenascin-C signaling pathway
which modify muscle’s exercise response and aerobic
performance and mitigate the molecular response of the
hypertensive patient to cardiovascular rehabilitation and
anti-hypertensive medication. A concept is discussed how
genetic, medical and training-log data can be combined
to a state-of-the-art approach to maximize muscle
performance through tailored exercise interventions.
e
:
martin.flueck@balgrist.ch