13 / 24
Page 43
allied
academies
Asian Journal of Biomedical and Pharmaceutical Sciences | ISSN: 2249-622X | Volume 8
&
Joint Event
Chemistry and Organic Chemistry
Biomedicine & Pharmacotherapy
International Conference on
8
th
World Congress on
October 22-23, 2018 | Frankfurt, Germany
Notes:
Diseases due to accumulation of macromolecular proteins caused to the human body and their removal
Paul S Malchesky
International Center for Artificial Organs &Transplantation, USA
O
ur biology and organ systems are designed to remove
toxins but in certain diseases and in aging there is an
accumulation of macromolecular proteins and pathological
molecules in abnormally high concentrations. It is believed also
that misfolding of proteins naturally occur during the aging
process as they are damaged and can cause diseases associated
with aging, such as certain cancers, Alzheimer’s and Parkinson’s.
In part protein accumulation results from impaired protein
degradation. Over 100 diseases of varying types affecting
our major organ systems are known to be associated with
abnormal or high concentrations of macromolecular proteins
and other chemistries. Various medical interventions, including
pharmacological agents, have failed to adequately “clear”
our bodies from these solutes and can be associated with
serious side effects. New approaches are needed but simply
put, can the removal alone of these pathological molecules
be supportive of healthier lives? Investigations in various
diseases with therapeutic apheresis as by plasma exchange
and plasma treatment with membranes and sorbents have
shown beneficial effects. In Alzheimer’s patients in two clinical
trials where plasma from young donors was administered (to
test the hypothesis that young molecules are important) or
replace plasma with albumin (to test the hypothesis that toxic
molecules are present) the results have not been definitive to
date. In the group of disease associated with cryoprecipitable
proteins investigations have shown that these proteins are
suppressive to the immunological system and that there
removal, such as by cryofiltration, improves cellular functions
as well as patient conditions. The apheresis procedure can
serve as “artificial senescent cells”, by removing abnormal and
damaged proteins. By removing the “biological smoke”, those
abnormally high concentration and toxic macromolecules,
the biological system can be activated to return to normalcy
and allow pharmacological agents to work more effectively.
e:
paulsmalchesky@aol.comChemistry and Biomedicine 2018, Volume 8
DOI: 10.4066/2249-622X-C4-012