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Asian Journal of Biomedical and Pharmaceutical Sciences | ISSN: 2249-622X | Volume 8
&
Joint Event
Chemistry and Organic Chemistry
Biomedicine & Pharmacotherapy
International Conference on
8
th
World Congress on
October 22-23, 2018 | Frankfurt, Germany
Gd
2
O
3
nanoparticles as a MRI contrast agents
Mohammad Wasi Ahmad
Dhofar University, Oman
M
agnetic resonance imaging (MRI) iswidelyused inmodern
clinical medicine as a diagnostic tool, and provides
noninvasive and three-dimensional visualization of biological
phenomena in living organisms with high spatial and temporal
resolution. Therefore, considerable attention has been paid to
magnetic nanoparticles as MRI contrast agents.
We report a facile method to synthesize high quality and bio-
functionalized Gd2O3 nanoparticles (BFNPs) for use as contrast
agents in MRI. The bonding status of BFNPs were confirmed
by FT-IR and TGA analysis. The surface coating amount was
estimated to be from 40% to 60% in weight percent from a TGA
analysis. High voltage electron microscope (HVEM) shows that
the BFNPs were spherical in shape with an average diameter
3M. In addition, the bio-compatibility of the nanoparticles
were measured by cytotoxicity tests by using human prostate
cancer (DU145) and normal mouse hepatocyte (NCTC1469)
cell lines which indicated that BFNPs are not toxic up to 250M.
BFNPs are paramagnetic but have an appreciable magnetic
moment at room temperature. This is because Gd(III) has seven
unpaired 4f-electrons (S = 7/2). Therefore, appreciable r1 and
r2 values are expected from sample solutions, which were in
fact observed in this study. The r1 and r2 values of BFNPs were
estimated to be 13.77 to 64.14 s -1mM -1 respectively. The high
relaxivities provide an opportunity to conduct perfusion MRI
experiments with significantly lower concentrations than those
needed for current commercial agents. A pronounced positive
and negative contrast enhancement was clearly observed in 3
tesla T1 MR images of a rat with a liver tumor after injection of
an aqueous sample solution into a rat tail vein.
e:
mdwasiahmad@gmail.comChemistry and Biomedicine 2018, Volume 8
DOI: 10.4066/2249-622X-C4-012