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Asian Journal of Biomedical and Pharmaceutical Sciences | ISSN: 2249-622X | Volume 8
&
Joint Event
Chemistry and Organic Chemistry
Biomedicine & Pharmacotherapy
International Conference on
8
th
World Congress on
October 22-23, 2018 | Frankfurt, Germany
Notes:
Assessing the quality of antimalarial drugs from India using MINILAB: A field study
Taruna Katyal Arora
National Institute of Malaria Research, India
S
ubstandard and counterfeit antimalarial medicines poses
a serious threat to public health. These counterfeit/
substandard medicines increases the mortality by decreasing
efficacy; it also increases the threat of emergence of drug
resistance, adverse effect from incorrect excipients/ active
ingredientswhichmay bepotentially dangerous to thepatients.
Owing to this, a pilot study was conducted to survey quality of
drugs collected from different malaria endemic areas of India.
The survey was conducted in different geographical regions
on the basis of malaria endemicity i.e. Uttar Pradesh (U.P.),
Mizoram, Meghalaya, Gujarat, Madhya Pradesh. Antimalarial
samples of ACT (Artesunate+Sulphadoxine-pyremethamine),
(Artesunate+Lumefantrine), Chloroquine, Primaquine were
collected for qualitative analysis. Amystery shopper approach
was used for collection of samples. The quality of antimalarial
drugs from these areas were assessed by using Global Pharma
Health Fund Minilab test kit. This includes physical/visual
inspection and disintegration test, thin-layer chromatography.
High performance liquid chromatography was carried
out for quantitative assessment of active pharmaceutical
ingredient. A total of 150 antimalarial samples were collected.
These samples includes 55 (Chloroqunie), 50 (Artemether
Lumefantrine), 14 (Artesunate Sulphadoxine-Pyrimethamine),
31 (Primaquine). These samples were assessed by quality
using GPHF minilab lab kit. In this study 98% of the tablets
passed minilab disintegration, 2% consisting did not passed
disintegration test. 99% of samples passed preliminary
Qualitative TLC test when compared with 100% and 80%
of the standards. 96% of samples passed quantitative HPLC
test, 4% of samples (contained low active pharmaceutical
ingredient) did not passed this test. The substandard drugs
circulating in the market causes drug resistance, treatment
failure and finally leads to death. Additional analysis such
as post-marketing surveillance should be done so that
good quality antimalarials reached to the population.
e:
tarunakatyal@gmail.comChemistry and Biomedicine 2018, Volume 8
DOI: 10.4066/2249-622X-C4-012