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Asian Journal of Biomedical and Pharmaceutical Sciences | ISSN: 2249-622X | Volume 8
&
Joint Event
Chemistry and Organic Chemistry
Biomedicine & Pharmacotherapy
International Conference on
8
th
World Congress on
October 22-23, 2018 | Frankfurt, Germany
Non enzymatic glucose sensor based on au-ru nanoparticleswith high resistance against chloride poisoning
Dhekra Ayed
University of Monastir, Tunisia
D
iabetes is the 6th most common cause of death and
can lead to serious and costly complications. To avoid
them, the patient must be able to manage his blood glucose
level. Great efforts have been devoted to improving glucose
biosensor to determine the glucose level. As enzymatic
glucose biosensors suffer frommany problems, non-enzymatic
glucose sensor based on nanoparticles was utilized to solve
these problems, because it shows good performances through
increasing the surface area and enhancing the mass transport
and catalysis. Bimetallic Au-Ru nanoparticles (NPs) with novel
core-shell morphology were prepared through a single-step
microemulsion synthesis for the decoration of multi-walled
carbon nanotubes (fMWCNTs). The presence of Ru leads to
particles with smaller diameters, improved distribution and
adhesion on fMWCNTs, affording very good accessibility to the
catalytic sites. To validate this elaborated structure, the effect of
Ru on the activity and effectiveness of the catalyst were studied
to detect glucose in alkaline solutions. Au-RuNPs/fMWCNTs
exhibitsahighsensitivityof 28.7μAmM−1cm−2 towardglucose
and provides a linear range for physiological concentrations
(1 mM – 10 mM). Contrary to Au, the Au-RuNPs/fMWCNTs
electrode is highly resistant against poisoning by chloride ions,
and the interference from the oxidation of common interfering
species is effectively suppressed. Additionally, the presence of
interfering species (fructose, galactose, ascorbic acid…) affects
only marginally the response toward glucose. The role of Ru
and the special core-shell morphology are discussed. The Au-
RuNPs/fMWCNTs electrode exhibits good selectivity, high
sensitivitytowardglucoseoxidationandapplicabilityforglucose
detection in real human serum samples, this is promising for
the future development of non-enzymatic glucose sensors.
e:
ayeddhekra@rocketmail.comChemistry and Biomedicine 2018, Volume 8
DOI: 10.4066/2249-622X-C4-012