8 / 28
allied
academies
May 13-14, 2019 | Prague, Czech Republic
Chemistry and Medicinal Chemistry
9
th
World Congress on
Page 21
Asian Journal of Biomedical and Pharmaceutical Sciences | Volume 9
ISSN: 2249-622X
T
he microwave (MW) technique has become an
important tool in organophosphorus chemistry
[1–3]. In this paper, the advantages of MWs in different
catalytic reactions are surveyed. The first case is, when
the MW-assisted direct esterification of phosphinic acids
becomes more efficient in the presence of an ionic liquid
catalyst. The second instance is, when catalytic reactions,
such as the phase transfer catalyzed (PTC) O-alkylation
of phosphinic acids, or the Arbuzov reaction of aryl
bromides are promoted further by MW irradiation. It is
also an option that MWs may substitute catalysts, such
as in the PTC alkylation of active methylene containing
P-derivatives, in Kabachnik–Fields condensations, and in
reluctant P=O deoxygenations. Another valuable finding of
ours is that in the Hirao P–C coupling applying Pd(OAc)
2
as
the catalyst, the slight excess of the >P(O)H reagent may
substitute the usual P-ligands. It is also the purpose of this
paper to elucidate the scope and limitations of the MW
tool, to interpret the special MW effects, and to model
the distribution and effect of the local overheatings. All
these considerations were possible on the basis of the
results of our quantum chemical calculations and utilizing
the pseudo first order kinetic equation and the Arrhenius
equation. The synthesis of dronic acid derivatives as drugs
in the therapy of bone diseases is also discussed.
Speaker Biography
György Keglevich graduated from the Technical University of Budapest
in 1981 as a chemical engineer. He got “Doctor of Chemical Science”
degree in 1994, in the subject of organophosphorus-chemistry. He
has been the Head of the Department of Organic Chemistry and
Technology since 1999. Within organophosphorus chemistry, his major
field embraces a P-heterocycles involving selective syntheses, as well
as bioactive and industrial aspects. He also deals with environmentally
friendly chemistry involving MW chemistry, its theoretical aspects,
phase transfer catalysis, the development of new chiral catalysts, and
the use of ionic liquids. He is the author or co-author of ca. 550 papers
(the majority of which appeared in international journals) including
ca. 70 review articles and 40 book chapters. He is, among others, the
member of the Editorial Board of Molecules, Heteroatom Chemistry
and Phosphorus, Sulfur and Silicon, and the Related Elements, and
Current Microwave Chemistry. He is the Editor-in-Chief for Current
Organic Chemistry and Current Green Chemistry, the co-Editor-in-Chief
for Current Catalysis, Associate Editor for Current Organic Synthesis and
Letters in Drug Design and Discovery, and Regional Editor for Letters in
Organic Chemistry.
e:
gkeglevich@mail.bme.huGyörgy Keglevich
Budapest University of Technology and Economics, Hungary
Microwave irradiation and catalysis in Organophosphorus Chemistry–
Green Synthesis of biologically active Organophosphorus Compounds
György Keglevich, Asian J Biomed Pharmaceut Sci, Volume:9
DOI: 10.4066/2249-622X-C2-019
Notes: