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May 13-14, 2019 | Prague, Czech Republic
Chemistry and Medicinal Chemistry
9
th
World Congress on
Page 17
Asian Journal of Biomedical and Pharmaceutical Sciences | Volume 9
ISSN: 2249-622X
T
he growing prevalence of metabolic syndrome (MetS) in
the US and even worldwide is becoming a serious health
problem and economic burden. MetS has become a crucial
risk factor for the development of Type 2 Diabetes Mellitus
(T2D) and Cardiovascular Diseases (CVD). In this seminar, we
discuss mechanisms of MetS pathogenesis and phytochemical
role from tea in control of glucose homeostasis focusing on the
Forkhead/winged helix transcription factor O-class member
1 (FoxO1), a key mediator of insulin and glucagon signaling
in control of glucose homeostasis. One of the most potent
phytochemicals from tea is
epigallocatechin gallate (EGCG)
that has been attracted interests owing to its potential to
combat hyperglycemic diabetes, but molecular mechanisms
underlying its antihyperglycemic effect, in particular the effect
on FoxO1 is poorly understand. This study aims to assess
the impact of EGCG on the glucagon signaling pathway in
regulating glucose metabolism. A novel mechanism of EGCG
in restraining Hepatic Glucose Production (HGP) is through
antagonizing glucagon signaling and Foxo1. EGCGmay serve as
a promising compound for regulating glucose homeostasis and
benefit to CVD.
Speaker Biography
Shaodong Guo is Associate Professor in the Department of Nutrition
and Food Science at Texas A&M University College. He received his Ph.
D in Physiology from Peking University, China. Then he completed his
postdoctoral research training in Genetics, Biochemistry, and Medicine
in the Chinese Academy of Sciences, the University of Illinois at Chicago,
and Harvard University, respectively. He was Instructor in Medicine
at Children's Hospital Boston and Harvard Medical School for two
years prior to joining the faculty at Texas A&M Health Science Center.
Currently, He serves as senior editor for the Journal of Endocrinology
and Journal of Molecular Endocrinology, two major official journals of
Endocrine Society of Europe, UK, and Australia, and he is the textbook
chapter writer for Metabolic Syndrome edited by Rexford Ahima and
published by Springer in 2016. His lab research focuses on insulin/
glucagon and estrogen signal transduction, insulin resistance, gene
transcriptional control of nutrient homeostasis, and cardiac dysfunction
in diabetes. He has been working on the gene transcriptional regulation
of metabolic homeostasis by insulin receptor substrate proteins (IRS)
and Forkhead FoxO transcription factors and he has been funded by
American Diabetes Association (ADA), American Heart Association, and
the National Institute of Health of USA. He is a recipient of ADA junior
faculty award, career development award, and Richard R Lee Research
Excellence Award. His work has been published in a number of journals
including the JBC, Endocrinology, Hypertension, Diabetes, Circulation
Research, AJP, MCB, and Nature Medicine, receiving more than 5,500
citations from the Google Scholar.
e:
Shaodong.guo@tamu.eduShaodong Guo
Texas A&M University, USA
Phytochemicals and Dietary Intervention in control of Diabetes,
Obesity and CVD
Shaodong Guo, Asian J Biomed Pharmaceut Sci, Volume:9
DOI: 10.4066/2249-622X-C2-019
Notes: