3 / 28
allied
academies
May 13-14, 2019 | Prague, Czech Republic
Chemistry and Medicinal Chemistry
9
th
World Congress on
Page 16
Asian Journal of Biomedical and Pharmaceutical Sciences | Volume 9
ISSN: 2249-622X
T
his talk will outline new strategies for assembling carbon-
rich conjugated structures. In the 1
st
part, I present alkynes
as unique high-energy synthetic precursors for extended
polyaromatics, the two general patterns of oligoalkyne folding
into a graphenic ribbons, and the use of supramolecular effects
in the design of radical cascades.
In the 2
nd
part, I will present a mild method for oxidative C-H
amination from unprotected anilines and C(sp
3
)-H bonds.
In this process, basic, radical, and oxidizing species work
together in a coordinated sequence of deprotonation, H-atom
transfer and electron transfer that forges a new C–N bond in a
conceptually unique manner. This approach leads to efficient
assembly of extended N-doped helicenes.
I will also introduce reductant upconversion, a new concept in
catalysis, and show how it can be used to achieve the precise
timing of oxidation steps in reaction cascades.
Speaker Biography
Igor V Alabugin received his Ph.D. degree from Moscow State
University, Russia. After a postdoctoral study at the University of
Wisconsin-Madison, he joined the Florida State University, Department
of Chemistry and Biochemistry in 2000, where he is currently the
Cottrell Professor. His efforts in the development of new reactions
for selective DNA cleavage in cancer cells, bioorthogonal chemistry,
functionalization of nanomaterials, and construction of graphene
ribbons are greatly assisted by fundamental studies of stereoelectronic
effects. He has published over 150 peer-reviewed research articles
and a book on stereoelectronic effects. He has also given ~ 200 talks at
conferences, universities and industries. He also serves on the editorial
board of three journals. His recent awards include selection as an AAAS
Fellow 2017 and Fulbright Fellow (2018).
e:
alabugin@chem.fsu.eduIgor V Alabugin
Florida State University, USA
From Alkyne Origami and Metal-Free C-H aminations to electron
upconversion: An array of new bottom-up approaches to Carbon-rich
molecules and materials
Igor V Alabugin, Asian J Biomed Pharmaceut Sci, Volume:9
DOI: 10.4066/2249-622X-C2-019
Notes: