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May 13-14, 2019 | Prague, Czech Republic
Chemistry and Medicinal Chemistry
9th World Congress on
Page 24
Asian Journal of Biomedical and Pharmaceutical Sciences | Volume 9 ISSN: 2249-622X
Stergios Pispas
National Hellenic Research Foundation, Greece
Cationic block copolymer based nanocarriers for Proteins and
Nucleic Acids
One of the goals of polymeric nanomedicine is the
creation of functional nanocarriers for pharmaceutical
compounds taking advantage of developments in polymer
synthesis and control over polymer self-assembly. The aim
of this presentation is to discuss block copolymer based
advanced nanocarriers for insulin and nucleic acids. We
have utilized several novel cationic block polyelectrolytes
for complexation with insulin and DNA/RNA as well block
copolymer micelles encapsulating magnetic iron oxide
nanoparticlesforintroducingmultifunctionalityinourpolymer
based nanocarriers. Static, dynamic and electrophoretic light
scattering techniques and transmission electron microscopy
were used in order to extract information on the size, charge
and morphological characteristics of the nanostructures.
Cytotoxicity, internalization into cells and gene transfection
studies were also performed in the case of DNA/RNA
carriers. Toxicity of nanocarrier systems was low. Application
of a magnetic field improved gene transfection in cell lines
investigated.
Speaker Biography
Stergios Pispas is Director of Research at TPCI-NHRF. He serves as the
chairman of the Scientific Council of TPCI-NHRF (since 2016) and an
Advisory BoardMember of the European Polymer Journal (2017) among
other editorial duties. He has been awarded the American Institute
of Chemists Foundation Award for Outstanding Post-doctoral Fellow
(1995) and the A. K. Doolittle Award of the American Chemical Society
(2003). He is a coauthor of more than 300 research articles in referred
journals, several invited review articles and three books, receiving more
than 7500 citations (h-index=40). His current research focuses on the
synthesis of functional block copolymers by controlled polymerizations
and the development of complex, hybrid, self-organized nanostructures
based on designed synthetic polymers and biomacromolecules and
inorganic nanomaterials for nanomedicine applications.
e:
Stergios Pispas, Asian J Biomed Pharmaceut Sci, Volume:9
DOI: 10.4066/2249-622X-C2-019
Notes: