chemistry-2019-keynote

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allied
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May 13-14, 2019 | Prague, Czech Republic
Chemistry and Medicinal Chemistry
9th World Congress on
Page 20
Asian Journal of Biomedical and Pharmaceutical Sciences | Volume 9 ISSN: 2249-622X
Awide range of polymeric membranes have been
synthesised for creating suitable biomaterials to provide
topographic, chemotactic, and haptotactic cues to improve
neuronal regeneration. Polymeric membranes thanks to
their selective structural, physico-chemical, mechanical and
transport properties, are able to drive neurite outgrowth
and branching, network connectivity, and synaptic plasticity
leading to the successful in vitro reconstruction of neuronal
tissue. Indeed, membranes can be employed to create an
in vitro neuronal tissue model for studying neurobiological
events, for pharmacological screening, and as investigational
platforms for neurodegenerative diseases. Within this
scenario, the approach was to synthesize microporous
polymer membranes combining the intrinsic properties of
the polymer as well as the geometry and configuration of the
membranes with the perfusion conditions of a bioreactor, in
order to develop a well-controlledmicroenvironment able to
trigger neuronal differentiation. The selectivepermeabilityof
the membranes and the optimized fluid dynamic conditions
created by the membrane bioreactor provide a 3D low-shear
stress environment fully controlled at molecular level with
enhanced diffusion of nutrients and waste removal that
successfully develops neuronal-like tissue. The membrane
platformwas used to reproduce anin vitro model of Amyloid
beta (Abeta)-induced toxicity associated to Alzheimer’s
disease to test the neuroprotective effect of molecules such
as crocin and glycitein. Using this approach, we showed the
neuroprotection of the administered molecules that inhibit
the cytotoxic event triggered by β-amyloidwhilemaintaining
high cell viability, reduces the number of cells in apoptosis
by inactivating specific protein markers and protects against
ROS production by highlighting an antioxidant action. Thus,
the membrane is an innovative investigational platform that
could be used to study neurodegenerative disorders as well
as neurobiological phenomena in order to gain new insights
on neurological functions and protection.
Speaker Biography
Loredana De Bartolo, PhD. in Chemical Technologies and NewMaterials,
is research director at the Institute on Membrane Technology of the
National Research Council of Italy (ITM-CNR). Her research expertise is
in the field of membrane bioartificial organs, membrane bioreactors,
membrane separation processes in life science. She is scientific
responsible of several European, national and international projects.
She is involved in several international committees and in editorial
board of prestigious scientific journals. She is author of over 150 papers
published in international journals/books and encyclopaedia and has
made numerous invited and keynote lectures to scientific meetings. She
was named International Fellow in World Federation on Preventive and
Regenerative Medicine and Alexander von Humboldt Fellow.
e:
Loredana De Bartolo
SMorelli, A Piscioneri, S Salerno, L Giorno and E Drioli
National Research Council of Italy, Italy
Polymeric membrane platform for testing the neuroprotective effect
of molecules in Alzheimer’s disease
Loredana De Bartolo et al., Asian J Biomed Pharmaceut Sci, Volume:9
DOI: 10.4066/2249-622X-C2-019
Notes: