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June 06-07, 2019 | London, UK
2nd International Conference on
Tissue Science and Molecular Biology,
Stem Cells & Separation Techniques
Joint Event
Biomedical Research (An International Journal of Medical Sciences) | ISSN: 0976-1683 Volume 30
The use of nutraceuticals in regenerative matrix repair in knee OA
Dennis M Lox
Sports and Regenerative Medicine Centers, USA
Nutraceuticals to facilitate the regenerative process,
after the use of matrix or stem cell applications in knee
osteoarthritis (OA) is examined. Pro-inflammatory cytokines
have been extensively studied in various disease models.
Recombinant technology in single cytokine modulation
has been utilized for various rheumatologic disease states,
incorporating blockadeof tumor necrosis factor alpha (TNF-a),
interleukin 1- beta (IL1-b) and interleukin 1-6 (IL-6). The
efficacy of mono cytokine inhibition on knee osteoarthritis
(OA) has failed to demonstrate. This is long known to be the
case in the well demonstrated progressive nature of knee
OA, with downstream inhibition of PGE2 with nonsteroidal
anti-inflammatory drugs (NSAIDS). The use of regenerative
therapies incorporating biological scaffolds, growth factors
and mesenchymal stem cell implants may provide a
more comprehensive cell signalling inhibitory pathway. A
combination approach, incorporating nutraceuticals based
upon clinical laboratory studies, may reflect a possible
synergistic mechanism to regenerative therapies. Knowledge
of the cytokine modulatory capacity of nutraceuticals can be
a useful adjuvant strategy in vivo to enhance regenerative
capacity.
Speaker Biography
Dennis M Lox graduated from the University of Arizona Phi Beta Kappa and
Phi Kappa Phi. His medical education was from Texas Tech University and
his residency in physical medicine and rehabilitation at the University of
Texas Health Sciences Centre at San Antonio. He chooses a path following
sports and regenerative medicine. He has edited two medical textbooks,
eight medical textbook chapters and authored numerous scientific
articles and abstracts. He is a highly sought-after guest lecturer at both
national and international medical symposiums on various topics in the
regenerative medicine, stem cell science and tissue engineering fields.
He maintains an active clinical practice in Beverly Hills, California and the
Tampa Bay, Florida area.
e:
Dennis M Lox, Biomed Res, Volume 30
ISSN: 0976-1683