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June 06-07, 2019 | London, UK
2
nd
International Conference on
Tissue Science and Molecular Biology,
Stem Cells & Separation Techniques
Joint Event
Biomedical Research (An International Journal of Medical Sciences) | ISSN: 0976-1683 Volume 30
Biochemical characterization of crucial domain RNA dependent helicase of dengue
virus (DENV)
Ayyub Patel
King Khalid University, Saudi Arabia
D
engue infection (DENV) is the reason for dengue fever. It
is a mosquito-borne single positive-stranded RNA virus
of the family Flaviviridae. Dengue infection has expanded
drastically during the recent most 20 years and is getting
to be one of the most exceedingly awful mosquito-borne
human pathogens tropical nations need to manage. Current
assessmentsdemonstratethatupwardsof390milliondiseases
happen every year and it is progressively comprehended
that various dengue contaminations are asymptomatic
or sub-clinical. DEAD-box proteins are associated with an
arrangement of metabolic procedures that regularly include
RNAs. However, now and again additionally other nucleic
acids are also included. DEAD-box RNA helicases assume
critical jobs in RNA digestion, for example, grafting, ribosome
biogenesis, RNA transport, debasement and interpretation.
In the present study, we report that dengue virus contains
RNA dependent ATPase activity and RNA unwinding activities.
Conclusion:
The biochemical studies revealed in in this
original copy are the important initial step to obtain new
insights into enzyme function and regulation. Overall, this
investigation is the main direct proof to demonstrate the
RNA helicase action of HABD protein has a place with DEAH
family. The HABD protein demonstrates the ATPase activity in
presence of RNA. Maximum energy provided in the presence
of ATP and dATP. This energy helps to unwind the RNA duplex.
This HABD protein may be useful for mitochondrial RNA
splicing, translation and genome maintenance.
Speaker Biography
Ayyub Patel currently working as an assistant professor in the
department of clinical biochemistry, King Khalid University. He does
research in biochemistry, spectroscopy, e-learning and medical
education. His current projects include: Promoting active learning in
medical students; Zamzam water and acid reflux, anti-cancer activity
of natural herbs and spices like qist albahri qist al Hindi, tumeric, gum
arabic, moringa seeds etc.
e:
ayyub@kku.edu.saAyyub Patel
, Biomed Res, Volume 30
ISSN: 0976-1683