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Journal of Biomedical Research | ISSN: 0976-1683 | Volume 30
March 14-15, 2019 | London, UK
T issue Engineer ing, Stem Cel ls and Regenerat ive Medicine
Cel l and Gene Therapy
World Congress on
International Conference on
&
Joint Event
Small periodontal involvement make big difference
Abed Al Rahman
Beirut Arab University, Lebanon
Lasers have been used in many different fields in medicine and
dentistry since their introduction in the 1960s. Lasers have
demonstrated bactericidal effects which are promising for
periodontal therapy, for this reason, laser therapy used as an
adjunct to conventional therapy, has been proposed as a novel
treatment option in controlling the subgingival microorganisms
and studying the shift in inflammatory mediators. This
study investigated cytokine profiles in response to diode
laser irradiation of chronic periodontal pockets to show an
inflammatory response to
P. ginvivalis
infection. The purpose of
the study was to reveal the activation profiles of inflammatory
cytokines in response to diode laser.
Material and methods:
This study was carried out as
randomized controlled clinical trial; split mouth design.
Twenty patients having generalized chronic periodontitis with
moderate clinical attachment loss, were treated randomly using
conventional treatment alone or with application of diode laser
on the other side. Blood panel and collection of GCF were taken
before starting the treatment for each patient and 2, 6 months
for follow up in order to compare the effect of diode laser as
an adjunctive therapy to scaling and root planning. All data was
collected for statistical analysis.
Results:
In this study, significant differences were found on
the three gingival crevicular fluid (GCF) cytokine levels tested
before and after periodontal therapy. C-reactive protein (CRP)
and tumor necrosis factor (TNF) alpha were the only cytokines
that decreased immediately after treatment and remained at
significantly lower levels until the end of the study period.
At two weeks following treatment of either scaling and root
planning alone or in conjunction of laser disinfection gingival
index (GI) level in the test site rangedbetween0.1 to0.5whereas
in the control site it was 0.5 to 1.25. As for the inflammatory
mediators IL-1β ranged between 20.12 to 24.48 in comparison
to 21.22 to 26.78 in control site. TNF alpha ranged from (1.01-
3.7) in comparison with (1.21 - 1.89) and CRP level was (0.39-
0.67) in comparison with (0.23-67).
In all parameters the test sites showed better decrease in the
inflammatory mediators and clinical parameters.
e:
Adshamleh@hotmail.comBiomed Res, Volume 30
DOI: 10.4066/biomedicalresearch-C1-026