10 / 18
Page 40
Notes:
allied
academies
Journal of Biomedical Research | ISSN: 0976-1683 | Volume 30
March 14-15, 2019 | London, UK
T issue Engineer ing, Stem Cel ls and Regenerat ive Medicine
Cel l and Gene Therapy
World Congress on
International Conference on
&
Joint Event
New class of biodegradable polymeric implants for bone regeneration
Farshad Oveissi
1
, Sina Naficy
1
, Iman Manavitehrani
2
, Ali Fathi
3
, Dax Calder
4
, Aaron Schindeler
1,2
, David Winlaw
1
and
Fariba Dehghani
1
1
The University of Sydney, Australia
2
The Children’s Hospital, Australia
3
Australian Technology Park, Australia
4
The University of Western Australia, Australia
T
he explantation surgery of an implanted prosthesis often
causes clinical complications and the patient suffers from
the countless post-surgical symptoms such as infection and
the lack of mobility. This issue has been clinically addressed
using biodegradable polymers such as poly (lactic acid) with
favourable physical and biological properties. However, the
acidic degradation of these polymers causes delays in the
tissue regeneration process and necrosis. We attempted to
address this issue by developing new classes of biomaterials.
For example, we introduce a biodegradable material based
on poly (propylene carbonate) (PPC) and starch with benign
degradation by-products that is only water and carbon dioxide.
This polymer has superior characteristics compared with other
polyesters. The results of
in vitro
and
in vivo
studies endorsed
the biocompatibility of this polymer blends. In addition, we
observed
in vivo
osseo integration effects of this implant
in a rat hemiarthroplasty model. Therefore, this product is
superior for orthopaedic fixation implantation. In yet another
study, we synthesized a thermo-responsive hydrogel with
the capacity to chemically bond with primary amine groups
of proteins. This hydrogel has favourable gelation time that
can be used as an injectable material for delivery of active
compounds. The results of
in vitro
and
in vivo
studies show
that this hydrogel is biocompatible with tenable mechanical
properties and adhesiveness that make them suitable for broad
tissue range of musculoskeletal repair. Our recent clinical study
demonstrates that this hydrogel can be used successfully for
socket preservation. We have also developed new class of
elastic hydrogels with superior properties that can be used for
3D printing.
e:
fariba.dehghani@sydney.edu.auBiomed Res, Volume 30
DOI: 10.4066/biomedicalresearch-C1-026