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academies
October 22-23, 2018 | Frankfurt, Germany
International Conference on
Robo t i c s a n d A u t oma t i o n
B iomater ial s and Nanomater ial s
Joint Event
&
Journal of Biomedical Research | Volume 29
Nanomedicinal constituents in herbal plants and species impact as antioxidant
Mohamed Sikkander A
Velammal Engineering College, India
N
anomedicine isayoungscience.Hownanotechnologycanbe
of use to medicine, medical technology and pharmacology
has only been researched since the 1990s. Nanotechnology
itself has only existed for a few decades. After the invention
of high resolution microscopy it evolved simultaneously
in biology, physics and chemistry in the course of the 20th
century and spawned new disciplines such as microelectronics,
biochemistry and molecular biology. For nanomedicine,
nanobiotechnology knowledge which investigates the structure
and function of cells as well as intra and intercellular processes
and cell communication is of prime importance. This research
only became possible at the beginning of the 20th century when
the door to the nanocosmos was burst open with the invention
of innovative microscopes. Herbal medicines have been widely
used around the world since ancient times. The advancement of
photochemical and phytopharmacological sciences has enabled
elucidation of the composition and biological activities of several
medicinal plant products. The effectiveness of many species of
medicinal plants depends on the supply of active compounds.
Most of the biologically active constituents of extracts, such as
flavonoids, tannins, and terpenoids, are highly soluble in water,
but have low absorption, because they are unable to cross the
lipid membranes of the cells, have excessively high molecular
size, or are poorly absorbed, resulting in loss of bioavailability
and efficacy. Some extracts are not used clinically because
of these obstacles. It has been widely proposed to combine
herbal medicine with nanotechnology, because nanostructured
systems might be able to potentiate the action of plant extracts,
reducing the required dose and side effects, and improving
activity. Nanosystems can deliver the active constituent at a
sufficient concentration during the entire treatment period,
directing it to the desired site of action. Conventional treatments
do not meet these requirements. The purpose of this study is to
review nanotechnology-based drug delivery systems and herbal
medicines.Natural productshavebeenused inmedicineformany
years. Many top-selling pharmaceuticals are natural compounds
or their derivatives. These plant or microorganism-derived
compounds have shown potential as therapeutic agents against
cancer, microbial infection, inflammation, and other disease
conditions. However, their success in clinical trials has been less
impressive, partly due to the compounds’ low bioavailability. The
incorporation of nanoparticles into a delivery system for natural
productswouldbeamajor advance in theefforts to increase their
therapeutic effects. Recently, advances have beenmade showing
that nanoparticles can significantly increase the bioavailability of
natural products both in vitro and in vivo. Nanotechnology has
demonstrated its capability to manipulate particles in order to
target specific areas of the body and control the release of drugs.
Although there are many benefits to applying nanotechnology
for better delivery of natural products, it is not without issues.
e:
fengppj@ku.ac.thRobotics & Biomaterials 2018, Volume 29
DOI: 10.4066/biomedicalresearch-C6-017