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allied
academies
October 22-23, 2018 | Frankfurt, Germany
International Conference on
Robo t i c s a n d A u t oma t i o n
B iomater ial s and Nanomater ial s
Joint Event
&
Journal of Biomedical Research | Volume 29
Hollow porous nanocapsules: Sustained delivery of immunomodulatory drugs and adjuvant properties
for the effective management of various infectious or tumor diseases
Pradip Paik
Indian Institute of Technology, India
S
ignificant efforts have been made over recent years to
design suitable delivery materials for efficient loading as
well as the controlled/sustained release of drugs. Out of various
materials which have been exported, polymeric colloidal
particles/nanocapsul es are of particular interest in which drug
can be encapsulated through absorption/conjugation onto the
surfaces or in the void space of the same. Their biocompatibility
and degradability, nontoxic and the ability to facilitate sustained
release of drugs, have attracted significant rese arch interest
as potential drug carriers over metal or inorganic, non-
biodegradable nanoparticles as drug delivery systems. Different
types of polymers; both synthetic and natural have been
utilized in the preparation of nanocapsules Polymeric hollow
nanocapsules have attracted significant research interest
as novel drug carriers and their preparation is of particular
concern for their feasibility to encapsulate a broad range of
drugmolecules.Thisworkpresentsforthefirsttimethesynthesis
and development of a novel poly-N-acryloyl L-phenylalanine
methylester hollowcorenanocapsules (NAPA-HPN’s) of Avg. size
ca. 100-150 nm prepared by mini-emulsion technique. NAPA-
HPN’s are biocompatible and capable of encapsulating sodium
nitro prusside (SNP) at a rate of ~ 1.3 µM per mg of capsules.
These NAPA-HPN’s + SNP nano-formulations while maintaining
homeostasis of macrophages which carries and facilitate the
action of various drug molecules used against the various
diseases. These NAPA-HPN’s also facilitated the prolonged
release of the low level of Nitric oxide(NO) and enhanced
metabolic activities of pro-inflammatory macrophages which
are important for the action of various drugs in body fluids.
NAPA-HPN’s mediated skewing of native macrophages toward
M1 phenotype potentially demonstrated its adjuvant action on
the innate immune system. These results potentially suggested
that NAPA-HPN’scan serve both as a carrier of the drugs
as well as an adjuvant for the immune system. Thus, these
nanocapsules could be used for the effective management of
various infectious or tumor diseaseswhere immune-stimulation
is paramount for treatment.
e:
paik.bme@
iitbhu.ac.inRobotics & Biomaterials 2018, Volume 29
DOI: 10.4066/biomedicalresearch-C6-017