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allied
academies
October 22-23, 2018 | Frankfurt, Germany
International Conference on
Robo t i c s a n d A u t oma t i o n
B iomater ial s and Nanomater ial s
Joint Event
&
Journal of Biomedical Research | Volume 29
The immobilization anti-tuberculosis drugs loaded -car-MA-INH/nano hydroxyapatite nanocomposites
for osteoarticular tuberculosis treatment
Marippan Rajan
Madurai Kamaraj University, India
T
uberculosis synovitis as often as possible introduces as
a monoarthritis of weight-bearing joints, for example,
the hip, knee, or lower leg. Early detection with a synovial
biopsy permits incite anti-tuberculosis (anti-TB) treatment
and considerably enhance the possibility of safeguarding of
joint structure and capacity. Beginning treatment ordinarily
incorporates mix treatment with four anti-TB drugs such
as isoniazid, rifampin, pyrazinamide, and ethambutol. In
addition, biocompatible polymers and bio-ceramic materials
have been realized to be vital to fabricate drug delivery and
bone regenerations that offer high drug loading and sustained
release with remarkable in vivo bioavailability. In the present
work, multi-drug delivery system was developed with the
combination Rifampicin and Isoniazid anti-TB drugs. Initially,
Isoniazid drug was tagged with -carrageenan grafted maleic
anhydride (-Car-MA-INH) and then it was cross linked with nano
hydroxyapatite (NHAP) via electrostatic interaction. Rifampicin
drug was loaded on -Car-MA-INH/NHAP/RF through ionic
gelation technique. The chemical modification and interaction
of drug to the nanocomposites was characterised by Fourier
transform infrared spectroscopy (FT-IR). The size and surface
charge of the nanocomposites was measured by a zetasizer
analysis. The crystalline nature and surface morphology was
identified using X-ray diffraction patterns (XRD), scanning
electron microscopy (SEM), and transmission electron
microscopy (TEM). In-vitro cell viability and cell adhesion
experiments showed that composites lower the cytotoxicity
effect against fibroblast cells (L929) and higher cell adhesion
against osteoblast likes cell (MG63). Since, the bio-ceramic
nano drug delivery systems could be potential scaffoldmaterials
for application for osteoarticular tuberculosis treatment.
e:
rajanm153@gmail.comRobotics & Biomaterials 2018, Volume 29
DOI: 10.4066/biomedicalresearch-C6-017