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allied
academies
17
th
International Conference on
4
th
International Conference on
NEUROLOGY AND NEUROSCIENCE
&
MENTAL HEALTH AND PRIMARY CARE
October 16-18, 2017 | Toronto, Canada
J Neurol Neurorehabil Res 2017 | Volume 2 Issue 3
Introduction:
Multiplesclerosis(MS)isachronicinflammatory
autoimmune demyelinating disorder of the central nervous
system (CNS). Due to the variable clinical course of MS, it
is classified into relapsing and progressive phases and three
phenotypes of relapsing remitting MS (RRMS), primary
progressive MS (PPMS), and secondary progressive MS
(SPMS). Caffeine is a central nervous system stimulant of the
methylxanthine class. It is the world´s most widely consumed
psychoactive drug. Recent scientific evidences showed that
caffeine intake could be associated with decreased mortality
from cardiovascular and neurological diseases, diabetes type
II, as well as from endometrial and liver cancer. Previous
studies on consumption of caffeine and (MS) have yielded
inconclusive results. We aimed to investigate whether
consumption of caffeine is associated with disability of MS.
Method:
126 patients with diagnosis of MS (42 RRMS,
42 PPMS and 42 SPMS) with MRI assessment of brain and
spinal cord were recruited from multiple sclerosis clinics in
Kashani Hospital of Isfahan University of Medical Sciences,
Isfahan, Iran included in the present study. A 168-item semi-
quantitative food frequency questionnaire (FFQ) was used
for assessment of dietary intake of caffeine. Medical history
questionnaire, EDSS and Fatigue questionnaire recorded
from all participants.
Results:
Mean±SD of EDSS and fatigue scale in SPMS and
PPMS groups was significantly higher than RRMS group.
Dietary intakes of caffeine in RRMS was higher that two
other subgroups but not significantly. There was a negative
significant association between caffeine intake and EDSS in
RRMS subgroup (r=-0.556, p=0.031). In addition, there was a
significant negative correlation between caffeine intake and
Fatigue scale in all participants (r=-0.312, p=0.028). Other
correlations were not significant. Age, gender, energy intake
and blood pressure were not confounder variables.
Conclusion:
Our study demonstrated that there is a negative
significant correlation between intakes of caffeine with
fatigue scale in all participants. In addition dietary intakes
of caffeine can decrease EDSS in RRMS patients and caffeine
consumption may exert a protective role against multiple
sclerosis. The concern of high caffeine intake is dehydration
induced caffeine. Further studies with larger sample sizes
and other population needed to prove this correlation.
e:
mbmaljaie@gmail.comRelationship between caffeine intake, EDSS and fatigue scale in patients with multiple sclerosis
Mohammad Bagher Maljaei, Vahid Shaygannejad
and
Omid Mirmosayyeb
Isfahan University, Iran