13 / 16
Page 65
allied
academies
17
th
International Conference on
4
th
International Conference on
NEUROLOGY AND NEUROSCIENCE
&
MENTAL HEALTH AND PRIMARY CARE
October 16-18, 2017 | Toronto, Canada
J Neurol Neurorehabil Res 2017 | Volume 2 Issue 3
Introduction:
Multiple sclerosis (MS) is a chronic
demyelinating disease of the nervous system which is the
most common cause of neurological irreversible disability
in young adults who are professionally and socially active
persons.Duetothevariableclinical courseofMS, it is classified
into relapsing and progressive phases and three phenotypes
of relapsing remitting MS (RRMS), primary progressive MS
(PPMS), and secondary progressive MS (SPMS). Assessment
of dietary intakes of fats is an approach that has been used to
evaluate diet-disease and diet-disability association.
Method:
126 patients with diagnosed MS (84 RRMS, 21
PPMS and 21 SPMS) with MRI assessment of brain and spinal
cord were recruited from multiple sclerosis clinic in Kashani
Hospital of Isfahan University of Medical Sciences, Isfahan,
Iran include from present cross-sectional study. A 168-item
semi-quantitative food frequency questionnaire was used for
assessment of dietary intakes of fatty acids. Medical history
questionnaire, Expanded Disability Status Scale (EDSS) and
Fatigue questionnaire record from all participants.
Results:
Mean±SD of EDSS and fatigue scale in SPMS and
PPMS groups was significant higher than RRMS group. There
was a negative significant correlation between intakes of
Polly Unsaturated Fatty Acids (PUFAs) including Linolenic
Acid (r=-0.418, p=0.018), Linoleic Acid (r=-0.312, p=0.031)
with EDSS in all participants. In addition, there was a
negative significant correlation between intakes of Mono
Unsaturated Fatty Acids (MUFAs) (r=-0.348, p=0.028) with
EDSS in all participants. Correlation between Saturated
Fatty Acids (SFAs) with EDSS (r=0.465, p=0.009) and fatigue
scale (r=0.298, p=0.043) was significantly positive in all
participants. Although correlation between total dietary fats
with EDSS and fatigue scale in all participants and subgroups
were positive, but was not significant. Age, gender and blood
pressure were not confounder variables. In addition, we
adjusted energy intakes in subgroups.
Conclusion:
Our study demonstrated that there is a positive
significant correlation between intakes of SFAs with EDSS
and fatigue scale in all participants. In addition, dietary
intakes PUFAs and MUFAs can decrease EDSS in all patients
with MS. Further studies with larger sample sizes and other
population needed to prove this correlation.
e:
mbmaljaie@gmail.comFats and multiple sclerosis: association between fats/oils intake and disability in patients with MS
Mohammad Bagher Maljaei, Vahid Shaygannejad
and
Omid Mirmosayyeb
Isfahan University, Iran