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allied
academies
17
th
International Conference on
4
th
International Conference on
NEUROLOGY AND NEUROSCIENCE
&
MENTAL HEALTH AND PRIMARY CARE
October 16-18, 2017 | Toronto, Canada
J Neurol Neurorehabil Res 2017 | Volume 2 Issue 3
Introduction:
Neuromyelitis Optica Spectrum Disease
(NMOSD) is an inflammatory disorder of the central nervous
system (CNS) that presents typically with relapses of optic
neuritis or transverse myelitis, in which IgG autoantibodies
against aquaporin-4 water channel protein probably play a
pathogenic role and IgG-NMO levels had correlation with
disability in this patient. Assessment of dietary intakes of
food groups is an approach that has been used to evaluate
diet-disease and diet-disability association.
Method:
68 patients with diagnosed NMOSD with MRI
assessment of brain and spinal cord, clinical symptoms and
IgG-NMO test were recruited from multiple sclerosis clinic in
Kashani Hospital of Isfahan University of Medical Sciences,
Isfahan, Iran, include from present cross-sectional study. A
168-item, semi-quantitative food frequency questionnaire
(FFQ) was used for assessment of dietary intakes of food
groups. Medical history questionnaire, Expanded Disability
Status Scale (EDSS) and Fatigue questionnaire record from
all participants.
Results:
Mean±SD of EDSS and fatigue scale in IgG-NMO
positive group was significant higher than IgG-NMO negative
group. There was a negative significant correlation between
intakes of whole grain (r=-0.312, p=0.031), fish (r=-0.452,
p=0.018) and fresh fruits (r=-0.365, p=0.026) with EDSS in
all participants and intakes of fresh vegetables (r=-0.394,
p=0.038) and EDSS in IgG-NMO negative subgroup. In
addition, therewas a negative significant correlation between
intakes fresh vegetables (r=-0.302, p=0.034) and fresh fruits
(r=-0.372, p=0.023) with fatigue scale in all participants.
Correlation between red and processed meats with EDSS
(r=0.512, p=0.002) and fatigue scale (r=0.439, p=0.020) was
significantly positive in all participants. Although correlation
between dietary intakes of dairy and vegetable oil with EDSS
and fatigue scale in all participants and subgroups were
negative, but was not significant.
Conclusion:
Our study demonstrated that there is a positive
significant correlation between intakes of red and processed
meat with EDSS and fatigue scale in all participants. In
addition dietary intakes of whole grain, fish and fresh fruits
can decrease EDSS in all patients with NMOSD. This is first
report of dietary intakes of food groups in NMOSD patients.
Further studies with larger sample sizes and other population
needed to prove this correlation.
e:
mbmaljaie@gmail.comDiet and neuromyelitis optica spectrum disorder; association between food group intakes and
disability in patients with NMOSD
Mohammad Bagher Maljaei, Vahid Shaygannejad
and
Omid Mirmosayyeb
Isfahan University of Medical Sciences, Iran