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allied
academies
Biol Med Case Rep 2017 | Volume 1 Issue 2
November 06-07, 2017 | New Orleans, USA
Nanomedicine & Healthcare
Global Meet on
A
s synthetic and pharmaceutical scientists have realized
that the development of new drugs alone is not
sufficient to ensure progress in drug therapy, development
of suitable drug carrier systems was considered a vital
strategy to overcome these problems. One of those drug
carrier systems is solid lipid nanoparticles (SLN), which have
been developed for various routes of administration with
several objectives including enhancement of bioavailability
of poor water soluble drugs. In order to be effective, an
orally delivered drug must avoid several potential barriers.
For example, it must avoid degradation by stomach acid and
gut lumen digestive enzymes; avoid metabolism by enzymes
in the gut wall cell; and avoid first-pass extraction by the
liver. Olmesartan medoxomil (OLM), a hypertensive drug
is practically insoluble in water and has oral bioavailability
of 26% and 99% plasma protein binding. It is on the basis
of its physicochemical and biopharmaceutical properties,
that the drug was selected as a candidate for SLN drug
delivery system. The purpose of the present study was to
investigate the bioavailability enhancement of OLM by solid
lipid nanoparticles. OLM loaded SLN was prepared by hot
homogenization and ultra-sonication method. Optimization
was by particle size, polydispersity index, shape and surface
morphology determination. Physicochemical and other
spectroscopic parameters on optimized formulations (F
3
and F
7
respectively) were determined.
In-vitro
drug release
studies were performed using dialysis bag. Bioavailability
studies were done using albino rats. The
in-vitro
drug release
study demonstrated that drug-loaded formulations gave
higher drug release than olmesartan medoxomil. Zero-order
kinetic model best described the release kinetics of the drug
from the formulations based on the correlation coefficient
values. When compared with the oral tablet of OLM, the
pharmacokinetics of OLM loaded SLN formulations exhibited
higher plasma drug concentration, larger area under the
curve, and more enhanced oral bioavailability.
e:
hannah.okorie@esut.edu.ngDevelopment, characterization and pharmacokinetics of olmesartan-loaded solid lipid nanoparticles
Okorie Hannah Ndidiamaka
Enugu State University of Science and Technology, Nigeria