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Biol Med Case Rep 2017 | Volume 1 Issue 2
November 06-07, 2017 | New Orleans, USA
Nanomedicine & Healthcare
Global Meet on
C
oumarin and p-coumaric acid have been implicated to
alleviate multiple disease conditions and nanoparticles
have been known to inhibit key proteins, individually but
in this study we are interested in assessing the anti-HIV
and anticoagulant properties of coumarin and p-coumaric
acid along with their synthesized fullerene conjugates and
fullerene. We isolated coumarin and p-coumaric acid from
endophytic fungi, alternaria species-1 from crotalaria pallida
leaf and characterized by UV, XRD, FTIR, and C13 NMR.
Subsequently, we synthesized the fullerene nanoparticles
using coumarin and p-coumaric acid separately. Two
coagulant proteins and nine HIV-1 proteins were selected
using iGEMDOCK. We report that p-coumaric acid has greater
interaction with coagulant proteins followed by coumarin
and fullerenes. Among HIV-1 proteins higher interaction
was observed with p-coumaric acid especially, HIV-1gp120.
However, upon conjugating fullerene to coumarin and
p-coumaric acid, coumarin-fullerene showed significantly
greater interaction with coagulant proteins and all HIV-
1 proteins, compared to p-coumaric acid-fullerene and
fullerene. Our in silico study, thus identifies nanoparticles
synthesized by fullerene conjugated to naturally occurring
coumarin and p-coumaric acid as a safe and cost effective
alternative strategy to treating HIV or its use as an
anticoagulant.
Keywords:
Alternaria species-1, coumarin, p-coumaric acid,
molecular docking, anticoagulant, anti-HIV
e:
yashas7bt51@dayanandasagar.eduIn silico study of anti-HIV and anticoagulant properties of coumarin and p-coumaric acid, fullerenes and
their respective conjugates
Yashas Devasurmutt
Dayananda Sagar College of Engineering, India