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Biol Med Case Rep 2017 | Volume 1 Issue 2
November 06-07, 2017 | New Orleans, USA
Nanomedicine & Healthcare
Global Meet on
I
ron oxide nanoparticles (FNPs) were synthesized by co-
precipitation method, followed by coating with chitosan
(CS) biopolymer and used as a nanocarrier for efficient
delivery of anticancer agent protocatechuic acid (PA).
The Fourier transform infrared spectra revealed that the
FNPs nanoparticles could be successfully coated with CS
polymer and PA as an active anticancer drug. The magnetic
measurements showed that the designed nanocarrier and
protocatechuic acid-chitosan-iron oxide nanocomposite (PA-
CS-FNP)were superparamagneticwhile the releaseof PA from
PA-CS-FNP nanocomposite was found to be in a sustained
manner and significantly lower in phosphate buffered
solution at pH 7.4 than pH 4.8, due to different release
mechanism. The spherical shape of nanosized FNPs and PA-
CS-FNP was observed by Transmission Electron Microscopy
(TEM) and loading of PA in the PA-CS-FNP nanocomposite
was estimated to be about 11.3 %. In addition, PA-CS-FNP
nanocomposite showed higher inhibitory effect to cancer
cell growth than free PA, without affecting normal fibroblast
(3T3) cell growth.
e:
farahnaz.barahuie@gmail.comProtocatechuic acid loaded chitosan coated iron oxide nanoparticles for cancer therapy
Farahnaz Barahuie
Sistan and Baluchestan University, Iran