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allied
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Biol Med Case Rep 2017 | Volume 1 Issue 2
November 06-07, 2017 | New Orleans, USA
Nanomedicine & Healthcare
Global Meet on
O
besity has become an increasing problem over recent
years. Nano lipo-vesicles thermogel of soy extract were
formulated and evaluated to reduce the size of adipose
tissue cells through percutaneous absorption. Phytosome
formulations were prepared with three different techniques:
solvent evaporation, anti-solvent precipitation and co-
solvency. Optimized formulae were selected using Design
Expert® (Version 7.0.0, Stat-Ease Inc. Minneapolis, MN)
the means of the highest entrapment efficiency, minimum
particle size and maximum drug release and then evaluated
for successful complex formation by means of FTIR. Particles
zeta potential was detected. Particles shape was evaluated
using TEM to insure particles spherical shape and non-
aggregation. Optimized phytosome formulae were involved
into selected thermogel formulation after evaluation of
different plain formulations for clarity, homogeneity, pH,
gel transforming temperature and viscosity. Phytosomal
thermogel formulation was then re-evaluated for its clarity,
homogeneity, pH and gel transforming temperature and for
its rheology behavior and permeation study.
In vivo
study
was done to ensure anti -obesity effect of soy phytosomal
hydrogel. Concisely, soy phytosomal thermogel was found to
have the ability to reduce the size of adipose tissue cells of
the abdomen in male albino rats.
e:
nermeen.magdy@nub.edu.egNanosizedsoyphytosome-basedthermogel as topical anti-obesityformulation:Anapproachforacceptable
level of evidence of an effective novel herbal weight loss product
Nermeen M Khalil
1
, Mohamed Rabeh
2
, Shahira F El-Menshawe
3
and
Adel A Ali
3
1
Nahda University, Egypt
2
Cairo University, Egypt
3
Beni-Suef University, Egypt