6 / 16
Page 36
Notes:
allied
academies
Biol Med Case Rep 2017 | Volume 1 Issue 2
November 06-07, 2017 | New Orleans, USA
Nanomedicine & Healthcare
Global Meet on
T
oxicoses caused by low-quality food, pharmaceutical
treatment or environmental pollution can be successfully
treated only due to the usage of different enterosorbents.
Nanosilicas (fumed silica) are the most advantageous
for binding toxins of protein origin. Moreover, they can
deactivate pathogenic flora, act as a carrier of chemical
and natural medicinal substances, and improve their
biological activity. When used in combination with several
types pf biopolymers, they may regulate the release rate of
active substances. The above-mentioned properties make
competitive advantage over products with similar purposes,
currently available on the market. Last time, it creates a
wide range of composite systems based on nanosilica, which
possess strong detoxifying effect, adaptogenic, antioxidant
and immune modulating properties, and to develop methods
of action prolongation immobilized on the surface of silica-
carrier biologically active substances and development
of efficient methods improving biological activity of
antibiotics due to specific binding of them by silicas or their
composites with biopolymeric agents. The most promising
is the usage of medicinal products and biologically active
additives, produced based on nanosilica, in industrial areas
and for people with low income. With the development
of nanochemistry, the unique ability of nanooxides to
participate in structuration of adjacent water layer was
discovered. Because of the interactions between water and
nanoparticles, interfacial water decomposes to produce a
system nanosized water clusters separated by silica particles.
It appears that properties of such nano-structured water are
very different from the properties of bulk water. Such water
is capable to have different dissolving abilities, for example
it does not dissolve polar compounds such as mineral
acids and hydrogen peroxide, and also it may form weakly
associated water domains with non-polar compounds and
not participate in formation of hydrogen bonds. As a result,
upon contact of silica nanoparticles with cellular objects a
strong effect on cell metabolism occurs which is probably
due to retention of nutrients and stimulation of receptor
systemnear the cell membranes. Then, due to the interaction
between nanoparticles of silica-carrier and immobilized
on its surface, biologically active substances stimulation
of mucous membrane cells will occur, which leads to the
growth of biological availability of the products. The main
problem in the area of development and introduction of
biologically active additives and pharmaceuticals is the
conduction of pre-clinical and clinical trials. Conduction of
such trials requires significant financial investments, which
small and medium-sized enterprises usually can’t afford.
At present time Macrosorb LT company together with the
Chuiko Institute of Surface Chemistry have developed a line
of ready to use biologically active additives for detoxification
of the body (Silasita), characterized by high antioxidant and
immunostimulating activity (Balzasil), for lymph purification
(Lymphodren), series of fitosils for preventive care and
treatment of number of diseases.
Speaker Biography
Lyudmila Suvorova is a candidate of medical sciences, an expert in the field of nano and
biotechnology in the direction of medicine. CEO of Macrosorb LT. The initiator of the
creation of the direction is the UNITED GLOBAL HEALTH, the health of the environment,
plants, animals, food safety and man in a closed cycle. Leader in the direction of
social and inclusive business, GREEN economy for transition countries; participant
of 4 projects HORIZON 2020 of the European Union. Suvorova L.A. Is a co-author of
12 scientific articles, co-author of the textbook for universities: “ NANOCHEMISTRY
in solving the problems of ENDO and exo ecology” and the author of 1 patent. .
The company MacrosorbLT conducts experimental work and the introduction into
practical application of Nanobiocomposite products in the field of nanomedicine and
agriculture, water and soil purification.
e:
milana@macrosorb.orgNanosilicas as bioactive substances, drug deliverymeans and activator of pharmacological actionof natural
or synthetic biologically active substances
L A Suvorova
1
and
V V Turov
2
1
Macrosor. LT, Europe
2
Chuiko Institute of Surface Chemistry, Ukraine