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Journal of Biomedical Research | Volume: 29
November 19-20, 2018 | Paris, France
Molecular Biology, Tissue Science and Regenerative Medicine
International Conference on
Joint Event
&
4th World Heart Congress
Microfluidic-assisted formation of highly monodisperse and ordered mesoporous silica bioglasses
microcapsules
Nizar Bchellaoui
University of Monastir, Tunisia
In this work developed recently an original approach using
droplet-based microfluidics and the ESE techniques for the
fabrication of well-defined monodisperse mesoporous silica
bio glasses (85S5) hollow microspheres (microcapsules) whose
size, shape and composition can be varied on demand. Our
original approach allows producing highly monodisperse
mesoporous and hollow silica bio glasses microspheres which
is much simpler and straight forward than the time consuming
and tedious standard technique as the latter relies on the use
of a sacrificial hard template on which silica solidifies and forms
a mesoporous shell, followed by the selective removal of the
template. Our approach consists of one-step procedure as
the formation of the silica shell is driven only by a control of
the balance between the solvent evaporation and the silica
solidification rates at the surface of the microdroplets. A step
in our approach is that the control of the evaporation process
is conducted outside the microfluidic channels since we use
highly diluted solutions of the silica precursor (TEOS) droplets
and a fluorinated oil as a carrier medium in which solvents
(water ad ethanol) contained in the droplets do not solubilize.
Understanding the broad variety of the observed behaviours is
highly relevant to many applications. We vary the size of the
microdroplets, the concentration of the precursor molecules
(TEOS), the nature of the surfactant used against coalescence.
e:
Molecular Biology & Heart Congress 2018, Volume 29
DOI: 10.4066/biomedicalresearch-C8-023