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Journal of Biomedical Research | Volume: 29
November 19-20, 2018 | Paris, France
Molecular Biology, Tissue Science and Regenerative Medicine
International Conference on
Joint Event
&
4
th
World Heart Congress
Cartography of meningococcal meningitis inMali: Serogroups, sequences and clones from 2006 to 2016
Coulibaly S
National Institute for Public Health Research of Bamako, Mali
Introduction:
Mali, a country in the heart of West Africa, is part
of the Lapeyssonnie meningitis belt. Traditionally, neisseria
meningitis serogroupA is responsible formostmajor epidemics.
After the introduction of MenAfriVac conjugate vaccine A in
Mali in 2010, serogroup A declined sharply in the country.
Method:
This is a retrospective study of surveillance data from
2006 to 2016 for meningococcal meningitis at the National
Institute of Public Health Research in Bamako. The data
collectionconcernedall confirmationsofNeisseriameningitisby
bacteriological and PCR. The datawas processed and analyzed
using Excel, Epi Info 3.5.4 and Health Mapper Version 4.2.
Results:
A total of 5549 CSF were registered at INRSP between
2006 and 2016, of which 1122 positive or 20.22%positivity. The
typical sequences and clones of neisseriameningitis circulating
inMali in the last 10yearswereNmA-ST_7_CC5, NmA-ST_2859_
CC5, NmC-ST_12446_CC10217, NmW-ST_11_CC11, NmW-
ST_11_CC11ET17 and NmX-ST181_CC181.
Conclusion:
Our data show that before introduction of
“MenAfriVac” in Mali, N. meningitis serogroup A ST_7 and
ST_2859 clonal complex 5 was the cause of most epidemics.
After introduction there is the appearance of N. meningitis
C-ST_12446 and N. meningitis X-ST_181.
e:
sbcoulibaly1@yahoo.frMolecular Biology & Heart Congress 2018, Volume 29
DOI: 10.4066/biomedicalresearch-C8-023