food-technology-biotechnology-2018-posters

14 / 22

Page 52
Notes:
allied
academies
Journal of Biotechnology and Phytochemistry| Volume: 2
October 25-26, 2018 | Frankfurt, Germany
Joint Event
Biotechnology & Medical Microbiology
World Congress on 3 rd International Conference on
Food Science & Technology
Malignant hyperthermia: Possible diagnostic tool by electromyography
Charles H Williams
The Williams Research Laboratory, USA
The evaluation of the action potential at the myoneural
junction in several muscles of the Malignant Hyperthermia
susceptible pig shows that the amplitude of the action potential
voltage is increased dramatically at the myoneural junction.
The duration of the amplitude of the action potential is also
significantly increased.These data, along with our other findings
lead us to develop a hypothesis that the sodium channels at
the myoneural junction were leaky in that they did not close
as quickly as normal pig sodium channels and thereby allow an
influx of sodium ions into muscle cells that had to be pumped
out by the Na-K ATPase. The pumping is an energetic process
that requires the expenditure of ATP energy sources and
simultaneously produced heat. The flow of sodium ion into
muscle cells was a concentration dependent process that dis
not expend energy. We observed core temperatures up to
118oF. core temperature over 106 oF are highly lethal. Other high
body temperatures may be caused by the same heat generating
mechanism during other disease states. The sodium channel
futile cycle provides a mechanism for generation heat to
maintain a normal body temperature inwarmblooded animals.
We would not expect to find this heat generating mechanism in
cold-blooded would be nice to have a detector that
would measure sodium ion flow during the action potential.
The changes in sodium ions at the membrane of the muscle are
designed to maintain the -90mv charge across the membrane.
Loss of the membrane charge leads to a lethal situation and the
death of the organism.
e