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World Biochem 2019 & Regenerative Medicine 2019 Journal of Genetics and Molecular Biology | Volume 3
Page 23
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
March 25-26, 2019 | Amsterdam, Netherlands
&
BIOCHEMISTRY AND ENZYMOLOGY
World Congress on
TISSUE ENGINEERING AND REGENERATIVE MEDICINE, STEM CELL RESEARCH
2nd Global Conference on
Joint Event on
MECHANISM OF GESTATIONAL DIABETES:
INSULIN RESISTANCE OR SECRETORY FAILURE?
The aim of the project was to obtain a better understanding of the bio-
chemical derangement that leads to hyperglycemia during pregnancy
in Bangladeshi women.
Gestational Diabetes Mellitus (GDM) is an emerging issue for health care
professionals. It is associated with adverse pregnancy outcome. In Bangla-
desh, an alarming frequency of GDM has been observed recently. Among
the risk factors identified in the literature, ethnicity appears to be the most
significant one. The trend toward increased maternal age, the epidemic of
obesity and diabetes, decrease in physical activity and adoption of mod-
ern lifestyle in developing countries may all contribute to an increase in
prevalence of GDM. However, genetic polymorphism seems to be inter-
posed to compound the issue. We have been investigating these issues
of GDM in our population. In this context, we have observed progressive
increase in insulin resistance (IR) resulting in compensatory increase in
insulin secretion as measured by C- peptide but not sufficient to the de-
gree of overcoming resistance. Appearance of many hormones, such as
hPL, prolactin, progesterone, cortisol and cytokine like TNF-α particularly
during late pregnancy antagonizes the effect of insulin and triggers a state
of IR. Among these biomarkers we have found fasting insulin, TNF-alpha
and fibrinogen to be increased significantly in women with GDM especial-
ly when associated with overweight compared to pregnancy with normal
glucose tolerance (NGT). On the other hand, prolactin, hPL, hs-CRP were
not found to differ between GDM and NGT. Apart from these, we also ob-
served higher frequency of single nucleotide polymorphism (SNP) for TC-
F7L2 rs7903146 gene in GDM particularly for young and lean mothers. In
conclusion, GDM is a constellation of involvement of multiple factors.
Hasanat MA, J Genet Mol Biol 2019, Volume 3
Hasanat MA working as professor in the De-
partment of Endocrinology, Bangabandhu
Sheikh Mujib Medical University (BSMMU),
Dhaka, Bangladesh and he obtained M Phil
and MD from Bangladesh Institute of Re-
search and Rehabilitation in Diabetes, En-
docrine and Metabolic Disorders (BIRDEM),
Dhaka, Bangladesh. He has published more
than 45 original articles. He achieved best
researcher award of BSMMU in 2016. His
major research areas are diabetes (including
GDM), PCOS and infertility, thyroid diseases
and other endocrine problems. His speeches
on GDM and thyroid autoimmunity are avail-
able in many websites. He is also working as
Editor (American Research Journal of Endo-
crinology, SciFed Obesity Research Journal,
International Journal of Diabetes, Global Sci-
entific Research Journals and Clinical Journal
of Diabetes Care and Control) and Assoc. ed-
itor (Obesity and Diabetes International) of
different open access journals.
Hasanat MA
Bangabandu Shekih Mujib Medical University, Bangladesh
BIOGRAPHY