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World Biochem 2019 & Regenerative Medicine 2019 Journal of Genetics and Molecular Biology | Volume 3
Page 38
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
March 25-26, 2019 | Amsterdam, Netherlands
&
BIOCHEMISTRY AND ENZYMOLOGY
World Congress on
TISSUE ENGINEERING AND REGENERATIVE MEDICINE, STEM CELL RESEARCH
2nd Global Conference on
Joint Event on
INVESTIGATING THE CELLULAR
DYNAMICS OF ORGANS
DEVELOPMENT AND CANCER USING
3D IMAGING
Rios implemented a novel 3D-imaging approach (with 3D glasses) to
perform innovative multicoloured lineage tracing studies to follow the
development and fate of mammary stem cells (MaSC) and descendant
progenitor cells in vivo in entire mammary gland. As stem cells divide they
produce clones of cells; using this imaging technique the fate of these in-
dividual clones could be tracked throughout various stages of mammary
gland development, including puberty, pregnancy and normal adult ho-
meostasis. This work provided the first in vivo evidence for the existence
of bipotent MaSCs, which give rise to the two cell lineages that constitute
the mammary ducts, the luminal and the myoepithelial cells, as well as
the presence of distinct long-lived unipotent progenitor cells. The cellular
dynamics observed at different developmental stages support a model in
which both stem and progenitor cells drive morphogenesis during puber-
ty, whereas bipotent MaSCs coordinate ductal homeostasis and remod-
elling of the adult mouse gland (Nature 2014, Nature Comm. 2016, NCB
2017). We have now specialized this 3D technology combined with the
multicolored reporter confetti to detect early aberrant cellular behaviour
in models of breast cancer and to visualise how cancerous cells, accord-
ing to their cell-of-origin, exit normal ductal homeostasis and survive to
self-organise into a solid tumour.
Anne Rios, J Genet Mol Biol 2019, Volume 3
Anne Rios obtained her PhD in 2011. Her
work represented a novel cell signalling
mechanism that triggers the differentiation
of a defined subset of cells within a stempool
(Nature, 2011). Then she joined in the labo-
ratory of professors Jane Visvader and Geoff
Lindeman focusing on breast cancer. In 2016,
she received the Medical Innovation Award
(Centenary Institute Lawrence Creative Prize
Winner) for her postdoctoral’s work (Nature,
2014). In 2017, she was appointed group
leader at the Princess Máxima Center and
head the Princess Máxima Imaging Centre.
She is currently investigating the cellular
mechanisms underlying pediactric and adult
solid tumor progression using State-of-the-
art imaging technologies.
Anne Rios
Princess Maxima Center of Pediatric Oncology, Netherlands
BIOGRAPHY