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J Parasit Dis Diagn Ther 2017
Volume 2 Issue 3
Tropical Medicine 2017
Notes:
Page 35
September 7-8, 2017 | Edinburgh, Scotland
4
th
International Conference on
Tropical Medicine, Infectious Diseases & Public Health
CHARACTERIZATION OF PATIENTS
WITH CARBAPENEMASE-PRODUCING
PSEUDOMONAS AERUGINOSA ISOLATES
IN A MEDIUM LEVEL HOSPITAL IN CHÍA,
COLOMBIA
Tatiana Pacheco
a
, Julio C. García
a
and
Sara Arias
a
a
University of La Sabana, Colombia
Introduction:
Carbapenemics have been used as one of the
most important antimicrobials against severe infection by
Pseudomonas aeruginosa
strains. The resistance against these
antimicrobials presents a complex epidemiology and despite
contonous report of clinical and epidemilogical updates in many
countries in Latin America and specifically in Colombia, there
are few studies.
Objective:
To describe the clinical characteristics of patients with
carbapenemase producing
Pseudomonas aeruginosa
isolates.
Material and methods Between January 2015 and April 2017,
a descriptive study has been performed. This study included
patients from 18 to 82 years old with average age of 52 years.
All of them with carbapenemase- producing Pseudomonas
aeruginosa.
Results:
It has been documented 37 infected patients; whose
93.1% had a history of antibiotic therapy, the main antibiotic
used was Meropenem in 48.64% of the patients treated. Among
the reported infections, the most frequent was the urinary
tract infection in 29.73% of the patients, followed by soft tissue
infection (24.32%), pneumonia and abdominal sepsis in 10.81%
of patients, then device-associated infection, surgical site
infection, and bacteremia (5.41% each). 72.97% of the patients
presented hospitalization in an intensive care unit with an average
stay of 19 days. 29.7% of patients received monotherapy, 27.02%
had double therapy, in 24.32% of the cases a triple therapy was
followed and in the remaining 10.81% there was a regimen of
more than three antibiotics. Mortality was 24.32%. Molecular
analysis was performed in 3 isolated samples with confirmation of
Pseudomona aeruginosa species and presence of carbapenemase
type KPC and VIM in the three samples, suggesting the presence
of a same clone in the institution.
Biography
Tatiana Pacheco was born in Convención, Colombia. She received the Medical
Doctor degree from National University of Colombia in 2009, since then she
has been working in several researches related to the imapact of Infectious
diseases in Colombian Population. Now she is attending her master degree in
Clinical Pharmacology at University of La Sabana in Bogotá, Colombia where
she works with the Therapeutic Evidence research group.
pacheco.tatiana@gmail.comTatiana Pacheco et al., J Parasit Dis Diagn Ther 2017