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J Parasit Dis Diagn Ther 2017
Volume 2 Issue 3
Tropical Medicine 2017
Notes:
Page 33
September 7-8, 2017 | Edinburgh, Scotland
4
th
International Conference on
Tropical Medicine, Infectious Diseases & Public Health
QUANTIFICATION OF COLISTIN PLASMA
LEVELS IN CRITICAL PATIENTS FROM
SABANACENTRO, COLOMBIA POPULATION
Diana Gonzalez
a
, Cuervo S
a
and
Bustos RHa Garcia JC
a
a
University of La Sabana, Colombia
A
ntimicrobial resistance to antibiotic treatment has
significantly increased in recent years, causing this to become
a public health problem. More than 70% of pathogenic bacteria
are resistant to at least one of the currently used antibiotics.
Recently, the use of Polymyxin E (Colistin) has been used as a
"last line" therapy in treatment of gram-negative multiresistant
bacteria. However, pharmacological knowledge about these
molecules is very weak, because their use has been discontinued
due to their high toxicity. In recent years, research has focused
on the determination of the pharmacokinetic parameters of
Colistimethate sodium, in order to find the optimal dose to
maintain an adequate benefit-risk balance. The aim of this study
was to determine Colistin plasma levels in patients infected
with multiresistant bacteria, from a Sabana Centro (Colombia)
population, by means of the standardization and validation of
a fast and simple methodology as high-performance liquid
chromatography (HPLC). Our results were standardized by
HPLC, and allowed to measure plasma levels in the study
population. The above, allows to presently guide the dosage of
Sodium Colistimethate, according to Colistin plasma levels.
Biography
Diana González is medical doctor interested in the evaluation of the relationship
between serum levels and therapeutic efficacy in the use of antimicrobial drugs
as well as the determination of antimicrobial resistance in the clinical setting
related to use of these molecules. Currently she is working in the Research
Group Therapeutic Evidence of the Faculty of Medicine of the University of
La Sabana. In addition, they have participated in speeches and conferences
regarding the safe and cost effective use of antimicrobial drugs in Colombia.
dianamaria616@hotmail.comDiana Gonzalez et al., J Parasit Dis Diagn Ther 2017