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J Parasit Dis Diagn Ther 2017
Volume 2 Issue 3
Tropical Medicine 2017
Notes:
Page 21
September 7-8, 2017 | Edinburgh, Scotland
4
th
International Conference on
Tropical Medicine, Infectious Diseases & Public Health
AN OUTBREAK OF DIARRHEA IN
MANDERA, KENYADUE TO ESCHERICHIA
COLI SEROGROUP O-UNTYPABLE
STRAIN THAT HADACODING GENE FOR
ENTEROAGGREGATIVE E. COLI HEAT-
STABLE ENTEROTOXIN 1
Yoshio Ichinose
a
, Erick Odoyo
a
, Martin Bundi
a
, Gabriel Miringu
a
, Sora
Guyo
a
, Shah Mohammad
a
, Sadayuki Ochi
b
and Samuel Kariuki
c
a
Nagasaki University Kenya Research Station, Kenya
b
Fujita Health University, Japan
C
kenya Medical Research Institute, Kenya
I
n an outbreak of gastroenteritis on 16 December 2009, in
Mandera, Kenya, Escherichia coli O-untypable (OUT)
strain was isolated from stool specimens of patients (18/24,
75%). The E. coli OUT organisms could not be assigned
to any of the recognized diarrheagenic groups of E. coli.
However, they possessed the EAggEC heat-stable enterotoxin
(EAST1) gene. The cell-free culture filtrate of EASTEC strain
isolated from the outbreak case induced a considerable
amount of fluid accumulation (FA) in suckling mouse
intestine, indicating production of an enterotoxic factor(s).
These results identify EASTEC as the etiological agent of the
diarrheal outbreak in Mandera. This is the first report, to our
knowledge, demonstrating the diarrheagenicity of EASTEC
by using an animal model. It is considered necessary to
characterize the FA factor(s) and to study dissemination of
the EASTEC strains producing the enterotoxic factor(s) to
assess the public health significance of the strains distributed
in the environment.
Biography
Yoshio Ichinose has been graduated with speciality including intenal medicine
and gynecology and obstetrician, and got a PhD degree, Postgraduate School
of Medicine, Nagasaki University in 1985. He joined School of Medicine,
University of the Ryukyus as an Assistant Professor afterwards served as a
Lecturer at Institute of Tropical Medicine, Nagasaki University at 1994. In 2006
he started working as Professor at Institute of Tropical Medicine, Nagasaki
University. Currently he is serving as Chief Representative of Kenya Research
Station (NUITM-KEMRI Project).
ichinose@nagasaki-u.ac.jpYoshio Ichinose et al., J Parasit Dis Diagn Ther 2017