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J Parasit Dis Diagn Ther 2017
Volume 2 Issue 3
Tropical Medicine 2017
Notes:
Page 20
September 7-8, 2017 | Edinburgh, Scotland
4
th
International Conference on
Tropical Medicine, Infectious Diseases & Public Health
COMBINATION THERAPY OF METHANOLIC
ROOT EXTRACTS OFT. AVICENNIOIDESAND
A. LEIOCARPUSAND ITS EFFECTONKIDNEY
AND HAEMATOLOGICAL PARAMETERS IN
MICE
Olusegun Matthew Akanbi
a
a
Adekunle Ajasin University, Nigeria
Introduction:
The resistance of Plasmodium species to drugs has
necessitated the search for more drugs. Anogeissus leiocarpus
and Terminalia avicennioides have been considered traditionally
for the treatment of malaria.
Aim:
This study assessed the efficacy of combination therapy
of methanolic bark extracts of Anogeissus leiocarpus and
Terminalia avicennioides on malaria parasite and its effect on
kidney and haematological parameters in mice infected with
Plasmodium berghei.
Methods:
Thirty-six mice were distributed into six groups.
The first group was not infected with the parasite (normal
control). The second group was infected but not treated
(negative control). The third group was infected and treated
with 5.0mg/kgbdwt of combisunate (positive control), while
the third, fourth and fifth groups were infected and treated
with 100, 200, and 400 mg/kgbdwt of combined methanolic
bark extracts of T. avicennioides andA. leiocarpus. Treatments
were administered for four days. Blood was taken daily from
the tail of mice for the assessment of parasitaemia.The animals
were sacrificed on the fifth day and the kidney homogenates
was collected into plain bottles, whole blood and serum were
taken into EDTA and plain bottles respectively
Results:
The results showed that the parasite clearance was
highest in the group treated with 400mg/kgbdwt and lowest
in the group treated with 100mg/kgbdwt. White blood cell,
lymphocyte, haemoglobin, red blood cell and MCHC levels
were significantly higher in normal control than in other groups.
Haemoglobin was significantly reduced in negative control, and
the groups treated with 100 and 400mg/kgbdwt when compared
with positive control and the group treated with 200mg. The
SGPT, SGOT, Potassium and creatinine levels were significantly
lower in the normal control than in the other groups.
Conclusion:
Though the antiplasmodia; activities of
combination therapy of the bark extracts of A.leiocarpus and
T.avicennioides was highest in the group treated with 400mg but
that concentration had serious negative effect on haematology
and kidney function of the animal.
Biography
Olusegun Matthew Akanbi is Currently working as a Associate Professor at
Department of Environmental Biology and Fisheries, Adekunle Ajasin University.
s_akanbi@hotmail.comOlusegun Matthew Akanbi, J Parasit Dis Diagn Ther 2017