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Journal of Clinical and Experimental Toxicology | Volume: 03 | ISSN: 2630-4570
allied
academies
November 04-05, 2019 | Prague, Czech Republic
2
nd
World Congress on
TOXICOLOGY AND APPLIED PHARMACOLOGY
Berberine as multi-targets therapeutic weapon against Alzheimer's disease
Doaa A Ghareeb
Alexandria University, Egypt
I
t is well known that berberine has several biological
activities like antioxidants, anti-inflammatory, antidiabetic,
antilipidemic and antitumor properties. Unfortunately,
this compound does not use as drug because it has low
bioavailability moreover, the plant that contains this
compound is not cultivated in Egypt. The aim of this study
was to understand the function of berberine as a treatment
for Alzheimer. To achieve this aim, the anti-Alzheimer/
anticancer effect of this compound at in silico,
in vitro
and
in vivo
level through targeting several pathways implicated
in disorder incidence and progression was investigated.
Moreover, two approaches in medical biotechnology
field were used to resolve berberine problems which are
Biocatalysis and nano-formulations. In conclusion, berberine
loaded nanoparticle is good candidate to treat Alzheimer
through targeting several pathways with no-toxic effect and
high therapeutic index.
Biography
Doaa A Ghareeb is the professor of clinical biochemistry at Faculty of
Science, Alexandria University. She is the Acting Dean of Pharmaceutical
and Fermentation Industries Development Centre, City of Scientific
Research and Technological Applications and the Manger of Biological
Screening and Preclinical Trial Lab, Department of Biochemistry,
Faculty of Science, Alexandria University. She is a member of National
committee of Women in Science, Academy of Scientific Research
and Technology, Egypt. She is the co-founder and director of Drug
Preclinical Studies Center of Excellency. She is among the founding
members of Egyptian Association for Cancer Research. Her h-index is 14
and published about 66 articles in peer-reviewed journals and attended
more than 80 national and international workshops and conferences
in different medical biotechnology field. She supervised more than 60
Master and PhD students from Egypt, and other countries and has been
serving as an editorial board member of reputed Journals.
e:
d.ghareeb@yahoo.comDoaa A Ghareeb, J Clin Exp Tox, Volume: 03
DOI: 10.35841/2630-4570-C2-008