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Journal of Clinical and Experimental Toxicology | Volume: 03 | ISSN: 2630-4570
allied
academies
November 04-05, 2019 | Prague, Czech Republic
2
nd
World Congress on
TOXICOLOGY AND APPLIED PHARMACOLOGY
Mechanistic
in vitro
Anti-Lung Cancer study of
Ceratonia siliqua
(Egyptian Carob) extract
Marwa El-Zeftawy
The New Valley University, Egypt
L
ung cancer (LC) is ranking the most predominant
cancer-related death worldwide. Tobacoo smoking and
environmental pollution with radiation and heavy metals
are considered the well- established contributing factors
of LC. Defect in the antioxidant system and inflammation
are two connected pathophysiological processes. The
complexity problem of LC is late diagnostic stage and limited
therapeutic options. Therefore, identification of effective
treatment is required to eliminate the rate of deaths. Herbal
medicine nowadays takes vast challenge as it has minimum
undesirable effects.
Ceratonia siliqua
(CS) is one of the well-
known Mediterranean plants which cultivated all over the
year and it is characterized by its cheap price and palatable
taste. The main aim of the current study is to determine the
phytoconstituent via HPLC technique and
in vitro
evaluation
of antioxidant and anti-inflammatory potentials of the CS
aqueous extract. Also, the anticancer effect of CS extract was
assessed using A549 cells. The extract showed high phenolic
content and significant antioxidant, anti-inflammatory and
anticancer effects. These findings could have important
impact in the LC treatment and could play a decisive role in
LC therapeutics.
Biography
Marwa El-Zeftawy has completed her PhD at age of 32 years from
Alexandria University, Egypt. She is a Lecturer of Biochemistry, Biochemistry
Department, Faculty of Veterinary Medicine, The New Valley University,
Egypt. She is the Principle Investigator of "Molecular and cellular
mechanistic activities of Ceratonia siliqua (Egyptian carob) in stabilizing
histone deacetylation and activating adult neurogenesis", STDF funded
project, 2019. She was a Scholarship Student, Comparative Pathobiology
Department, Faculty of Veterinary Medicine, Purdue University, West
Lafayette, Indiana, USA (20 April 2015 till 10 July 2015). She has 2
internationalpublicationsthathavebeencited14times,andherpublication
H-index is 2 and she has been serving as a reviewer member of some
journals. She is member in The Egyptian Association for Cancer Research,
(2015, till Now). She was participating in INTEL BASEF 2015 District fairs in
Alexandria, judgment.
e:
marwa_3_1983@yahoo.comMarwa El-Zeftawy, J Clin Exp Tox, Volume: 03
DOI: 10.35841/2630-4570-C2-008