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Biomedical Research
|
Volume 29
Page 42
allied
academies
CARDIOLOGY AND CARDIOVASCULAR MEDICINE
STEM CELLS AND REGENERATIVE MEDICINE
&
International Conference on
International Conference on
J u n e 1 8 - 1 9 , 2 0 1 8 | O s a k a , J a p a n
Joint Event on
MECHANISMS MEDIATING VASCULAR OCCLUSION IN
THROMBOIN FLAMMATORY DISEASES: ROLE OF THIOL
ISOMERASES
Jaehyung Cho
University of Illinois, USA
R
eal-time intravital microscopic studies have provided compelling evidence that intravascular cell-cell aggregation directly
contributes to vascular occlusion and tissue damage, a leading cause of morbidity andmortality of patients with cardiovascular
diseases. In particular, platelet-leukocyte interactions on the activated endothelium are crucial for the initiation and progression
of thrombotic and inflammatory diseases. Platelet-leukocyte adhesion is mediated mainly through the interactions of platelet
P-selectin and glycoprotein Ibα with neutrophil P-selectin glycoprotein ligand-1 and αMβ2 integrin, respectively. Despite our
knowledge of the major receptors and counter-receptors, it remains poorly understood how the receptor-counter-receptor
interactions are controlled during cardiovascular diseases. Evidence is mounting that the function of plasma proteins and
cell surface receptors involved in thrombosis and inflammation is controlled by oxidation or reduction of allosteric disulfide
bonds. Thiol isomerases catalyze thiol-disulfide exchange and regulate protein folding and function. Intriguingly, despite having
an endoplasmic reticulum retention signal, several thiol isomerases are released from intravascular cells and detected in the
circulation and on the cell surface. We have demonstrated that the plasma level of protein disulfide isomerase (PDI), a prototypic
thiol isomerase, is enhanced during thrombosis and vascular inflammation and that extracellular PDI plays a critical role in platelet-
leukocyte aggregation under thromboinflammatory conditions. In this presentation, I will discuss the molecular mechanism by
which PDI participates in the initiation and progression of thromboinflammatory diseases. A better understanding of themolecular
basis of thiol isomerase-mediated cell-cell interactions will provide insights into the development of novel therapeutic agents for
the prevention and treatment of cardiovascular diseases.
thromres@uic.eduBiomed Res 2018, Volume 29 | DOI: 10.4066/biomedicalresearch-C2-006