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Biomedical Research

Volume 29

Page 44

allied

academies

CARDIOLOGY AND CARDIOVASCULAR MEDICINE

STEM CELLS AND REGENERATIVE MEDICINE

International Conference on

J u n e 1 8 - 1 9 , 2 0 1 8 | O s a k a , J a p a n

Joint Event on

BRIHH IN PATIENTS WITH DM REPERCUSSION AND DIAGNOSIS

IN STUDIES OF MYOCARDIAL PERFUSION WITH SESTAMIBI

Gómez Garibo José Rubén

Naval General Hospital of High Specialty, Mexico

t is known that the LBBH has different etiologies, among which, wemust consider the obstructive coronary atherosclerosis,

mainly in the anterior descending coronary artery, however, there have been no analyzes that specifically assess the

presence of LBBH in diabetic patients and its Impact on myocardial perfusion studies with sestamibi. The purpose of this

study is to know if the diabetic patient, with LBBB, will increase the probability that said blockade is related to obstructive

coronary atherosclerosis, detected by myocardial perfusion studies, with sestamibi as a radiopharmaceutical. Additionally,

the diagnostic accuracy of the study will be assessed to adequately characterize the absence or presence of CAD. In a

retrospective way, 128 patients with LBBH were selected, sent to the nuclear medicine service from 2013 to 2016, with

suspicion of CAD. Of these patients, 68 (41 women and 27 men, average age 65 years, age range of 54 to 88 years) had

diabetes mellitus, among other known risk factors. The remaining 60 patients (36 women and 24 men, average age 69

years, age range of 54 to 88 years), suffered from other risk factors other than diabetes. The patients followed the protocol

for the preparation and conduct of myocardial perfusion studies of the American guidelines. Patients without BRDHH were

excluded. Stress tests of all patients were performed with dipyridamole. The reference test against which the results were

compared, was therapeutic coronary angiography, in the patients who were found to have CAD by our method. And when

the treating physician considered it, in patients without CAD by our method, coronary angiotomography was

the 68 patients with diabetes mellitus, 52 were found to have CAD and 16 without CAD. Of the 60 non-diabetic patients,

48 were found to have CAD and 12 without CAD. The chi square test was used to establish a relationship between the

known variables (diabetes and branch block / non-diabetics and branch blockade, healthy and sick). The null influence of

diabetes mellitus on the increase in CAD in patients with LBBH, was considered as a null hypothesis. The result was that

such hypothesis was confirmed. Regarding the diagnostic accuracy of the nuclear medicine study in patients with diabetes,

it was 94.1%, sensitivity of 94.2% and specificity of 93.8%. In non-diabetic patients, the diagnostic accuracy of the nuclear

medicine study was 93.8%, sensitivity of 93.8% and specificity of 93.8%. In both cases, positive predictive values were

found, above 97%.

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Biomed Res 2018, Volume 29 | DOI: 10.4066/biomedicalresearch-C2-006